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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lin-7  -  Protein LIN-7

Caenorhabditis elegans

 
 
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High impact information on lin-7

  • Furthermore, compensatory mutations in lin-7 and let-23 exhibit allele-specific suppression of apical mislocalization and signaling-defective phenotypes [1].
  • LET-23 overexpression rescues the lin-2 or lin-7 vulvaless phenotype, suggesting that increased receptor density can compensate for mislocalization [2].
  • In addition to these gene products, the lin-2, lin-7, and lin-10 products are also implicated in this pathway [3].
 

Anatomical context of lin-7

  • In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective [2].
 

Physical interactions of lin-7

  • The product of C. elegans lin-7 directly interacts with let-23 RTK and localize it at epithelial junctions [4].

References

  1. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Kaech, S.M., Whitfield, C.W., Kim, S.K. Cell (1998) [Pubmed]
  2. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Simske, J.S., Kaech, S.M., Harp, S.A., Kim, S.K. Cell (1996) [Pubmed]
  3. Molecular cloning and characterization of rat lin-10. Ide, N., Hirao, K., Hata, Y., Takeuchi, M., Irie, M., Yao, I., Deguchi, M., Toyoda, A., Nishioka, H., Mizoguchi, A., Takai, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Isolation and characterization of mammalian homologues of Caenorhabditis elegans lin-7: localization at cell-cell junctions. Irie, M., Hata, Y., Deguchi, M., Ide, N., Hirao, K., Yao, I., Nishioka, H., Takai, Y. Oncogene (1999) [Pubmed]
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