Disease relevance of Methyltransferase

• A novel methyltransferase catalyzes the methyl esterification of trans-aconitate in Escherichia coli [1].
• A highly active protein repair enzyme from an extreme thermophile: the L-isoaspartyl methyltransferase from Thermotoga maritima [2].

High impact information on Methyltransferase

• MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line [3].
• The C. elegans gene for the methyltransferase, designated pcm-1, was mapped to a single site in a 31 kb region in the central portion of chromosome V. The gene is 3.2 kb in length and includes six introns [4].
• A large class of the AdoMet-dependent methyltransferases shares a common binding motif for the AdoMet cofactor in the form of a seven-strand twisted beta-sheet; this structural similarity is mirrored in a degenerate sequence similarity that we refer to as methyltransferase signature motifs [5].
• We have analyzed existing methodologies and created novel methodologies for the automatic assignment of S-adenosylmethionine (AdoMet)-dependent methyltransferase functionality to genomic open reading frames based on predicted protein sequences [5].

Analytical, diagnostic and therapeutic context of Methyltransferase

• We report here the construction and the characterization of an animal model deficient in this methyltransferase [6].

References