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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

wrm-1  -  Protein WRM-1

Caenorhabditis elegans

 
 
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High impact information on wrm-1

  • Genetic experiments confirmed that one gene (JC8.6) identified by the gene recommender acts with lin-35 Rb to regulate vulval cell fates, and that another gene (wrm-1) acts antagonistically [1].
  • Two other Wnt pathway regulators, wrm-1 and lit-1, have the same effect as pop-1 on Z1/Z4 asymmetry [2].
  • Therefore, wrm-1 and lit-1 are required for pop-1 function, rather than opposing it as observed in the early embryo [2].

References

  1. A gene recommender algorithm to identify coexpressed genes in C. elegans. Owen, A.B., Stuart, J., Mach, K., Villeneuve, A.M., Kim, S. Genome Res. (2003) [Pubmed]
  2. POP-1 controls axis formation during early gonadogenesis in C. elegans. Siegfried, K.R., Kimble, J. Development (2002) [Pubmed]
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