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Gene Review

lin-36  -  Protein LIN-36

Caenorhabditis elegans

 
 
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Disease relevance of lin-36

  • The Caenorhabditis elegans gene lin-36 acts to antagonize Ras-mediated vulval induction in a pathway that includes genes with products similar to the mammalian retinoblastoma (Rb) protein and the Rb-binding protein p48 [1].
 

High impact information on lin-36

  • The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway [1].
  • We also report that the lin-36 pathway and/or another pathway that is functionally redundant with the lin-36 pathway antagonize a ligand-independent activity of the receptor tyrosine kinase/Ras vulval induction pathway [1].
 

Other interactions of lin-36

  • These data are consistent with lin-35 Rb, efl-1, and lin-36 acting in a common pathway or complex that negatively regulates G(1) progression [2].

References

  1. The C. elegans gene lin-36 acts cell autonomously in the lin-35 Rb pathway. Thomas, J.H., Horvitz, H.R. Development (1999) [Pubmed]
  2. C. elegans class B synthetic multivulva genes act in G(1) regulation. Boxem, M., van den Heuvel, S. Curr. Biol. (2002) [Pubmed]
 
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