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Gene Review

mog-1  -  Protein MOG-1

Caenorhabditis elegans

 
 
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High impact information on mog-1

  • Thirdly, we find that each of six genes, mog-1-mog-6, is required for repression by the fem-3 3' UTR [1].
  • Previous work showed that at least six mog genes are required for repression by the fem-3 3' untranslated region, and that one of those genes, mog-1, encodes a DEAH-box protein [2].
  • Three mog-1 alleles possess premature stop codons and are likely to be null alleles, and one is a missense mutation and is likely to retain residual activity. mog-1 mRNA is expressed in both germ line and somatic tissues and appears to be ubiquitous [3].
  • Therefore, we propose that wild-type mog-1 is required in the hermaphrodite germ line for regulation of the switch from spermatogenesis to oogenesis rather than for specification of oogenesis per se [4].
  • Therefore, in mog-1 mutants, germ cells that normally would become oocytes are transformed into sperm [4].
 

Biological context of mog-1

 

Anatomical context of mog-1

  • In addition to its involvement in the sperm-oocyte switch and control of fem-3, zygotic mog-1 is required for robust germ line proliferation and for normal growth during development [3].
 

Regulatory relationships of mog-1

  • A loss of mog-1 might inappropriately activate fem-3 and thereby abolish the sperm/oocyte switch; its loss might also lead to misregulation of maternal RNAs and thus embryonic death [4].
 

Other interactions of mog-1

  • We propose that the mog-2-mog-6 mutations identify genes that act with mog-1 to effect the sperm/oocyte switch [5].

References

 
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