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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

sbp-1  -  Protein SBP-1

Caenorhabditis elegans

 
 
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High impact information on sbp-1

  • An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis [1].
  • Thus, many physiological abnormalities caused by azacoprostane-mediated sterol metabolism disturbance appear to be exerted at least in part through SREBP pathway in C. elegans [2].
 

Biological context of sbp-1

  • Taken together, our findings demonstrate that ARC105 is a key effector of SREBP-dependent gene regulation and control of lipid homeostasis in metazoans [1].
 

Associations of sbp-1 with chemical compounds

  • The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis [1].

References

  1. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang, F., Vought, B.W., Satterlee, J.S., Walker, A.K., Jim Sun, Z.Y., Watts, J.L., DeBeaumont, R., Saito, R.M., Hyberts, S.G., Yang, S., Macol, C., Iyer, L., Tjian, R., van den Heuvel, S., Hart, A.C., Wagner, G., Näär, A.M. Nature (2006) [Pubmed]
  2. Proteomic changes during disturbance of cholesterol metabolism by azacoprostane treatment in Caenorhabditis elegans. Choi, B.K., Chitwood, D.J., Paik, Y.K. Mol. Cell Proteomics (2003) [Pubmed]
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