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Gene Review:

unc-25 - Protein UNC-25

Caenorhabditis elegans

Jin, Y. et al., Eastman, C. et al., McIntire, S.L. et al.

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High impact information on unc-25

The gene unc-25 is necessary for GABA expression and probably encodes the GABA biosynthetic enzyme glutamic acid decarboxylase [1].
The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development [2].
In unc-25 mutants the GABAergic neurons have normal axonal trajectories and synaptic connectivity, and the size and shape of synaptic vesicles are normal [2].
Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein [3].
The ectopic expression of UNC-30 induced the ectopic expression of reporter genes driven by the wild-type unc-25 and unc-47 promoters [3].

Biological context of unc-25

Mutations in the UNC-30 binding sites of the unc-25 and unc-47 promoters abolished the expression of reporter genes in the D neurons [3].

Associations of unc-25 with chemical compounds

Null mutations in unc-25 eliminate the UNC-25 protein or alter amino acids conserved in all known GADs, result in a complete lack of GABA, and cause defects in all GABA-mediated behaviors [2].

References

Genes required for GABA function in Caenorhabditis elegans. McIntire, S.L., Jorgensen, E., Horvitz, H.R. Nature (1993) [Pubmed]
The Caenorhabditis elegans gene unc-25 encodes glutamic acid decarboxylase and is required for synaptic transmission but not synaptic development. Jin, Y., Jorgensen, E., Hartwieg, E., Horvitz, H.R. J. Neurosci. (1999) [Pubmed]
Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein. Eastman, C., Horvitz, H.R., Jin, Y. J. Neurosci. (1999) [Pubmed]

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