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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pkg-1  -  Protein PKG-1

Caenorhabditis elegans

 
 
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High impact information on egl-4

  • We show that the egl-4 gene encodes cGMP-dependent protein kinases. egl-4 promoter::gfp fusion genes are mainly expressed in head neurons, hypodermis, intestine and body wall muscles [1].
  • The results indicate that volumes of intestine, hypodermis and muscle and cell volumes in intestine and muscle are increased in the egl-4 mutants, whereas cell numbers are not [1].
  • The multiple phenotypes of egl-4 dominant mutants are consistent with an instructive signaling role of PKG to control many aspects of animal physiology [2].
  • A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans [2].
  • We show here that egl-4 has many pleiotropies, including defects in chemosensory behavior, body size, synaptic transmission, and dauer formation [3].
 

Associations of egl-4 with chemical compounds

  • We show that a permeable cGMP analogue 8-Br-cGMP significantly reduces body size of the wild-type but not that of an egl-4 mutant, indicating that cGMP controls body size through EGL-4 [4].
 

Analytical, diagnostic and therapeutic context of egl-4

  • Recently, mutants in the egl-4 gene encoding cGMP-dependent protein kinases were found to have a larger body size, and it was suggested that EGL-4 down-regulates the TGFbeta/DBL-1 pathway [4].

References

  1. Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. Hirose, T., Nakano, Y., Nagamatsu, Y., Misumi, T., Ohta, H., Ohshima, Y. Development (2003) [Pubmed]
  2. A novel gain-of-function mutant of the cyclic GMP-dependent protein kinase egl-4 affects multiple physiological processes in Caenorhabditis elegans. Raizen, D.M., Cullison, K.M., Pack, A.I., Sundaram, M.V. Genetics (2006) [Pubmed]
  3. egl-4 acts through a transforming growth factor-beta/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues. Daniels, S.A., Ailion, M., Thomas, J.H., Sengupta, P. Genetics (2000) [Pubmed]
  4. cGMP and a germ-line signal control body size in C. elegans through cGMP-dependent protein kinase EGL-4. Nakano, Y., Nagamatsu, Y., Ohshima, Y. Genes Cells (2004) [Pubmed]
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