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Gene Review:

vha-11 - Protein VHA-11

Caenorhabditis elegans

Oka, T. et al., Oka, T. et al., Oka, T. et al.

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High impact information on vha-11

RNA interference analysis showed that the double-stranded RNA for unc-32 caused embryonic lethality similar to that seen with other subunit genes (vha-1, vha-4, and vha-11) (Oka, T., and Futai, M. (2000) J. Biol. Chem. 275, 29556-29561) [1].
RNA interference could efficiently silence vha-11 gene expression: introduction of vha-11 double strand RNA led to embryonic lethality [2].
Another new gene, vha-11, contained seven exons and was found to be located immediately downstream of vha-3 [3].

References

Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. Oka, T., Toyomura, T., Honjo, K., Wada, Y., Futai, M. J. Biol. Chem. (2001) [Pubmed]
Requirement of V-ATPase for ovulation and embryogenesis in Caenorhabditis elegans. Oka, T., Futai, M. J. Biol. Chem. (2000) [Pubmed]
Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cell-specific distribution. Oka, T., Yamamoto, R., Futai, M. J. Biol. Chem. (1998) [Pubmed]

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