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Gene Review

mt-Nd3  -  NADH dehydrogenase 3, mitochondrial

Mus musculus

Synonyms: Mtnd3, NADH dehydrogenase subunit 3, NADH-ubiquinone oxidoreductase chain 3, ND3, Nd3, ...
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Disease relevance of mt-Nd3

  • Passive protective immunity in Balb/c mice was demonstrated with monoclonal antibodies Nd2 and Nd3 in ascites fluid which stunted both male and female worms and reduced parasite fecundity [1].
  • We demonstrated that in the Paracoccus denitrificans NDH-1 subunit, Nqo7 (ND3) directly interacts with peripheral subunits Nqo6 (PSST) and Nqo4 (49 kDa) by using cross-linkers (Di Bernardo, S., and Yagi, T. (2001) FEBS Lett. 508, 385-388 and Kao, M.-C., Matsuno-Yagi, A., and Yagi, T. (2004) Biochemistry 43, 3750-3755) [2].
  • Hypothyroidism decreases ND3 mRNA levels in several brain areas such as cortex and hippocampus during the early postnatal development [3].

High impact information on mt-Nd3


Biological context of mt-Nd3


Anatomical context of mt-Nd3

  • The brain origin of mouse synaptosome cybrid mtDNAs was confirmed using sequence polymorphisms in the mtDNA COIII, ND3 and tRNA(Arg)genes [7].


  1. Nematospiroides dubius: passive transfer of protective immunity to mice with monoclonal antibodies. East, I.J., Washington, E.A., Brindley, P.J., Monroy, G.F., Scott-Young, N. Exp. Parasitol. (1988) [Pubmed]
  2. Functional roles of four conserved charged residues in the membrane domain subunit NuoA of the proton-translocating NADH-quinone oxidoreductase from Escherichia coli. Kao, M.C., Di Bernardo, S., Perego, M., Nakamaru-Ogiso, E., Matsuno-Yagi, A., Yagi, T. J. Biol. Chem. (2004) [Pubmed]
  3. Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis. Iglesias, T., Caubín, J., Zaballos, A., Bernal, J., Muñoz, A. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  4. Nonneutral evolution at the mitochondrial NADH dehydrogenase subunit 3 gene in mice. Nachman, M.W., Boyer, S.N., Aquadro, C.F. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Nature of steady-state and newly synthesized mitochondrial messenger ribonucleic acids in mouse liver and Ehrlich ascites tumor cells. Bhat, K.S., Kantharaj, G.R., Avadhani, N.G. Biochemistry (1984) [Pubmed]
  6. Ecological genetics of adaptive color polymorphism in pocket mice: geographic variation in selected and neutral genes. Hoekstra, H.E., Drumm, K.E., Nachman, M.W. Evolution (2004) [Pubmed]
  7. Cloning of neuronal mtDNA variants in cultured cells by synaptosome fusion with mtDNA-less cells. Trounce, I., Schmiedel, J., Yen, H.C., Hosseini, S., Brown, M.D., Olson, J.J., Wallace, D.C. Nucleic Acids Res. (2000) [Pubmed]
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