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Gene Review

mt-Nd4  -  NADH dehydrogenase 4, mitochondrial

Mus musculus

Synonyms: AL024073, AL024289, AU018658, AU019464, Mtnd4, ...
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Disease relevance of mt-Nd4

  • The characteristics of ND4 suggest that it may be of value in monitoring patients with colorectal carcinomas who do not have plasma CEA elevations [1].
  • One of 11 (9%) noncolonic tumors, a gastric adenocarcinoma, stained with ND4 [1].
  • METHODS: Adult male Swiss-Webster ND4 mice were repeatedly preconditioned with systemic hypoxia (RHP) over 12 days; 4 weeks later, the mice were subjected to 30 minutes of unilateral retinal ischemia [2].
  • In contrast, the mutant ND4 disrupted mitochondrial cytoarchitecture, elevated reactive oxygen species, induced swelling of the optic nerve head, and induced apoptosis, with a progressive demise of ganglion cells in the retina and their axons comprising the optic nerve [3].
  • Anesthetized and ventilated Swiss-Webster ND4 mice, wild-type mice, and NO synthase knockout mice were subjected to a 1-h period of EH (twelve 30-s periods of hypoxia every 5 min) [4].

High impact information on mt-Nd4


Chemical compound and disease context of mt-Nd4


Anatomical context of mt-Nd4


  1. A cell surface glycoprotein expressed by colorectal carcinomas including poorly differentiated, noncarcinoembryonic antigen-producing colorectal tumors. Salem, R.R., Wolf, B.C., Sears, H.F., Thomas, P., Bollinger, B., Zamcheck, N., Saravis, C.A., Chen, L.B., Steele, G. Cancer Res. (1988) [Pubmed]
  2. Long-Term Tolerance to Retinal Ischemia by Repetitive Hypoxic Preconditioning: Role of HIF-1{alpha} and Heme Oxygenase-1. Zhu, Y., Zhang, Y., Ojwang, B.A., Brantley, M.A., Gidday, J.M. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  3. The Mutant Human ND4 Subunit of Complex I Induces Optic Neuropathy in the Mouse. Qi, X., Sun, L., Lewin, A.S., Hauswirth, W.W., Guy, J. Invest. Ophthalmol. Vis. Sci. (2007) [Pubmed]
  4. Cerebrovascular inflammation after brief episodic hypoxia: modulation by neuronal and endothelial nitric oxide synthase. Altay, T., Gonzales, E.R., Park, T.S., Gidday, J.M. J. Appl. Physiol. (2004) [Pubmed]
  5. Efficiencies of different genes and different tree-building methods in recovering a known vertebrate phylogeny. Russo, C.A., Takezaki, N., Nei, M. Mol. Biol. Evol. (1996) [Pubmed]
  6. Mouse models of retinal ischemic tolerance. Zhu, Y., Ohlemiller, K.K., McMahan, B.K., Gidday, J.M. Invest. Ophthalmol. Vis. Sci. (2002) [Pubmed]
  7. Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. Lappas, G.D., Karl, I.E., Hotchkiss, R.S. Shock (1994) [Pubmed]
  8. Shared tumor antigens in colorectal carcinoma and neuroendocrine tumors. Tobi, M., Darmon, E., Rozen, P., Baratz, M., Lundqvist, M., Oberg, K., Thomas, P., Esteban, J., Hefta, S., Paxton, R., Shively, J. Cancer Detect. Prev. (1998) [Pubmed]
  9. Monoclonal antibodies binding to the cell surface of Listeria monocytogenes serotype 4b. Lin, M., Todoric, D., Mallory, M., Luo, B.S., Trottier, E., Dan, H. J. Med. Microbiol. (2006) [Pubmed]
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