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Gene Review:

rme-2 - Protein RME-2

Caenorhabditis elegans

Lee, M.H. et al., Matyash, V. et al.

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High impact information on rme-2

Comparisons of GLD-1-mediated translational control of rme-2 and tra-2 suggests that the mechanisms may differ for distinct target mRNA species [1].
For one target, the rme-2 yolk receptor mRNA, GLD-1 acts as a translational repressor to spatially restrict RME-2 accumulation, and thus yolk uptake, to late-stage oocytes [1].
The major proteins were identified as vitellogenins. rme-2 mutants, which lack the vitellogenin receptor, fail to accumulate dehydroergosterol in oocytes and embryos and instead accumulate dehydroergosterol in the body cavity along with vitellogenin [2].

References

Identification of in vivo mRNA targets of GLD-1, a maxi-KH motif containing protein required for C. elegans germ cell development. Lee, M.H., Schedl, T. Genes Dev. (2001) [Pubmed]
Distribution and transport of cholesterol in Caenorhabditis elegans. Matyash, V., Geier, C., Henske, A., Mukherjee, S., Hirsh, D., Thiele, C., Grant, B., Maxfield, F.R., Kurzchalia, T.V. Mol. Biol. Cell (2001) [Pubmed]

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