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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

deb-1  -  Protein DEB-1

Caenorhabditis elegans

 
 
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High impact information on deb-1

  • Actin filaments in the body wall muscle of the nematode Caenorhabditis elegans are attached to the sarcolemma through vinculin-containing structures called dense bodies, Z-line analogues [1].
  • The mutants were paralyzed and had disorganized muscle, a phenotype consistent with the idea that vinculin is essential for muscle function in the nematode [1].
  • PAT-6/actopaxin is not required for the deposition of UNC-52/perlecan in the basal lamina, nor for the initiation of attachment assembly, including the clustering of integrin into foci and the recruitment of attachment proteins PAT-4/ILK, UNC-112, and DEB-1/vinculin from the cytosol [2].
  • Affinity chromatography of nematode extracts on a column of immobilized HSP25 resulted in specific binding of vinculin and alpha-actinin but not actin, as revealed by Western blotting [3].

References

  1. Vinculin is essential for muscle function in the nematode. Barstead, R.J., Waterston, R.H. J. Cell Biol. (1991) [Pubmed]
  2. C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo. Lin, X., Qadota, H., Moerman, D.G., Williams, B.D. Curr. Biol. (2003) [Pubmed]
  3. HSP25, a small heat shock protein associated with dense bodies and M-lines of body wall muscle in Caenorhabditis elegans. Ding, L., Candido, E.P. J. Biol. Chem. (2000) [Pubmed]
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