The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Mt4  -  metallothionein 4

Mus musculus

Synonyms: MT-4, MT-IV, Metallothionein-4, Metallothionein-IV
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Mt4

  • Heterologous Escherichia coli expression in cultures supplemented with zinc, cadmium, or copper was achieved for MT4 and for its separate alphaMT4 and betaMT4 domains as well as for MT1 and its alphaMT1 domain in cadmium-enriched medium [1].
 

High impact information on Mt4

  • Here we report on the organization, stability, and the pathway of metal-thiolate cluster assembly in MT-4 reconstituted with Cd(2+) and Co(2+) ions [2].
  • Conversely, the entire MT4 and both of its domains showed better Cu(I) binding properties than MT1, affording Cu(10)-MT4, Cu(5)-alphaMT4 and Cu(7)-betaMT4, stoichiometries that make the domain dependence toward Cu(I) clear [1].
  • The in vivo conformed metal complexes and the in vitro substituted zinc/cadmium and zinc/copper MT4 aggregates were characterized [1].
  • Double staining of spleen sections for IFN-gamma and surface Ag revealed that 5 to 7 days after TNP-Ficoll immunization, +/- 40% of the IFN-gamma-PC expressed the MT4 Ag (CD4), +/- 50% the Lyt-2+ Ag (CD8) and +/- 10% the asialo-GM1 Ag (NK cell) [3].
  • Only with the MT5 and MT4 promoters were lines obtained that resembled secondary Schwann cells in culture in their morphology, generation time, and demonstration of contact inhibition [4].
 

Anatomical context of Mt4

  • Immunohistochemical staining was performed to localize the expression of MT4- and MT5-MMP in the mouse corneas [5].
  • This is the first report on metallothionein IV expression in the murine hair follicle; its expression domain almost completely overlaps that of Whn [6].
 

Associations of Mt4 with chemical compounds

  • We suppose the negative charge of the beta-domain of MT-4 prevents the EDTA attack to MT-4 [7].
  • Dosage-dependent release of 45Ca from mouse calvarial bones was observed after 120 hr of culture with 10(-6)-10(-8) MT4 and 10(-6)-10(-10) M T3 [8].
  • In contrast, stimulation of 45Ca release from mouse calvarial bones by 10(-7) MT4 and 10(-8) MT3 was not inhibited by 10(-6) M indomethacin [8].
  • Following this criterion, we determined that chloride anions are bound to the Cd(7)-MT1 and Cd(4)-alphaMT1 complexes but not in the isostoichiometric Zn complexes, nor in the Zn- or Cd-complexes of the homologous MT4 peptides [9].
  • Thus, in this work, the ckMT metal binding abilities towards Zn(II), Cd(II) and Cu(I) have been thoroughly revisited and then compared with those of the mammalian MT1 and MT4 isoforms, identified as zinc- and copper-thioneins, respectively [10].
 

Other interactions of Mt4

  • Studies reported herein examine the expression and regulation of the MT-III and MT-IV genes in specific cell types in the maternal reproductive tract, developing embryo, and fetus known to express the MT-I and -II genes [11].
  • The metal-thiolate clusters in MT-3 show different property and activity to the reactions compared with MT-4 and MT-1 [7].
 

Analytical, diagnostic and therapeutic context of Mt4

References

  1. Functional differentiation in the mammalian metallothionein gene family: metal binding features of mouse MT4 and comparison with its paralog MT1. Tío, L., Villarreal, L., Atrian, S., Capdevila, M. J. Biol. Chem. (2004) [Pubmed]
  2. Organization and assembly of metal-thiolate clusters in epithelium-specific metallothionein-4. Meloni, G., Zovo, K., Kazantseva, J., Palumaa, P., Vasák, M. J. Biol. Chem. (2006) [Pubmed]
  3. In vivo kinetics and characterization of IFN-gamma-producing cells during a thymus-independent immune response. van den Eertwegh, A.J., Fasbender, M.J., Schellekens, M.M., van Oudenaren, A., Boersma, W.J., Claassen, E. J. Immunol. (1991) [Pubmed]
  4. Isolation of rat Schwann cell lines: use of SV40 T antigen gene regulated by synthetic metallothionein promoters. Peden, K.W., Charles, C., Sanders, L., Tennekoon, G.I. Exp. Cell Res. (1989) [Pubmed]
  5. Expression of membrane-type matrix metalloproteinases 4, 5, and 6 in mouse corneas infected with P. aeruginosa. Dong, Z., Katar, M., Alousi, S., Berk, R.S. Invest. Ophthalmol. Vis. Sci. (2001) [Pubmed]
  6. Expression domains in the skin of genes affected by the nude mutation and identified by gene expression profiling. Schlake, T., Boehm, T. Mech. Dev. (2001) [Pubmed]
  7. The properties of the metal-thiolate clusters in recombinant mouse metallothionein-4. Cai, B., Zheng, Q., Huang, Z.X. Protein J. (2005) [Pubmed]
  8. Prostaglandin-independent stimulation of bone resorption in mouse calvariae and in isolated rat osteoclasts by thyroid hormones (T4, and T3). Conaway, H.H., Ransjö, M., Lerner, U.H. Proc. Soc. Exp. Biol. Med. (1998) [Pubmed]
  9. Influence of chloride ligands on the structure of Zn- and Cd-metallothionein species. Villarreal, L., Tío, L., Atrian, S., Capdevila, M. Arch. Biochem. Biophys. (2005) [Pubmed]
  10. Comparative metal binding and genomic analysis of the avian (chicken) and mammalian metallothionein. Villarreal, L., Tío, L., Capdevila, M., Atrian, S. FEBS J. (2006) [Pubmed]
  11. Activation of the complete mouse metallothionein gene locus in the maternal deciduum. Liang, L., Fu, K., Lee, D.K., Sobieski, R.J., Dalton, T., Andrews, G.K. Mol. Reprod. Dev. (1996) [Pubmed]
 
WikiGenes - Universities