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Gene Review

pxf-1  -  Protein PXF-1

Caenorhabditis elegans

 
 
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High impact information on pxf-1

  • In addition, the lethal phenotype of pxf-1 can be rescued by expression of an activated version of rap-1 [1].
  • Deletion of the catalytic domain from pxf-1 leads to hypodermal defects, resulting in lethality [1].
  • Particularly striking is the oscillating expression of pxf-1 in the pharynx during the four larval molts [1].
  • Green fluorescent protein (GFP) reporter constructs demonstrate that sites of pxf-1 expression include the hypodermis and gut [1].
  • The cuticle secreted by pxf-1 mutants is disorganized and can often not be shed during molting [1].
 

Other interactions of pxf-1

References

  1. Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Pellis-van Berkel, W., Verheijen, M.H., Cuppen, E., Asahina, M., de Rooij, J., Jansen, G., Plasterk, R.H., Bos, J.L., Zwartkruis, F.J. Mol. Biol. Cell (2005) [Pubmed]
 
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