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Gene Review:

dpy-26 - Protein DPY-26

Caenorhabditis elegans

Meneely, P.M. et al., Plenefisch, J.D. et al., Chuang, P.T. et al.

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High impact information on dpy-26

This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27 [1].
In addition we show that recessive mutations in two autosomal genes, dpy-21 V and dpy-26 IV, suppress the phenotypes resulting from the X-linked hypomorphic mutations, but not the phenotypes resulting from comparable autosomal hypomorphic mutations [2].

Biological context of dpy-26

Mutations in the genes dpy-26, dpy-27, dpy-28, and the newly identified gene dpy-29 disrupt dosage compensation, resulting in elevated X-linked gene expression in XX animals and an incompletely penetrant maternal-effect XX-specific lethality [3].

References

Sex-specific assembly of a dosage compensation complex on the nematode X chromosome. Chuang, P.T., Lieb, J.D., Meyer, B.J. Science (1996) [Pubmed]
Genetic analysis of X-chromosome dosage compensation in Caenorhabditis elegans. Meneely, P.M., Wood, W.B. Genetics (1987) [Pubmed]
Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans. Plenefisch, J.D., DeLong, L., Meyer, B.J. Genetics (1989) [Pubmed]

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