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Gene Review

Commd1  -  COMM domain containing 1

Mus musculus

Synonyms: AI256843, COMM domain-containing protein 1, Murr1, Protein Murr1, U2/Mu
 
 
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Disease relevance of Commd1

 

High impact information on Commd1

  • The mouse Murr1 gene contains an imprinted gene, U2af1-rs1, in its first intron [2].
  • Although none of the three human U2af1-related genes have been mapped to chromosome 2, the human homolog of Murr1 is assigned to chromosome 2 [3].
  • An analysis of genome structure of this gene revealed that the whole gene is located in an intron of the Murr1 gene [3].
  • Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice [4].
 

Biological context of Commd1

 

Analytical, diagnostic and therapeutic context of Commd1

  • In situ hybridization experiments that used the adult brain indicated that Murr1 gene was maternally expressed in neuronal cells in all regions of the brain [2].

References

  1. Toxicity and antiviral activity of cinnabarin obtained from Pycnoporus sanguineus (Fr.) Murr. Smânia, A., Marques, C.J., Smânia, E.F., Zanetti, C.R., Carobrez, S.G., Tramonte, R., Loguercio-Leite, C. Phytotherapy research : PTR. (2003) [Pubmed]
  2. The mouse Murr1 gene is imprinted in the adult brain, presumably due to transcriptional interference by the antisense-oriented U2af1-rs1 gene. Wang, Y., Joh, K., Masuko, S., Yatsuki, H., Soejima, H., Nabetani, A., Beechey, C.V., Okinami, S., Mukai, T. Mol. Cell. Biol. (2004) [Pubmed]
  3. Mouse U2af1-rs1 is a neomorphic imprinted gene. Nabetani, A., Hatada, I., Morisaki, H., Oshimura, M., Mukai, T. Mol. Cell. Biol. (1997) [Pubmed]
  4. Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice. Zhang, Z., Joh, K., Yatsuki, H., Wang, Y., Arai, Y., Soejima, H., Higashimoto, K., Iwasaka, T., Mukai, T. Gene (2006) [Pubmed]
 
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