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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mvk  -  mevalonate kinase

Mus musculus

Synonyms: 2310010A05Rik, AI256848, AI414037, MK, Mevalonate kinase
 
 
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Disease relevance of Mvk

 

High impact information on Mvk

  • Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease [1].
  • PS/2, R1-2, or MK2 significantly inhibited the recruitment of eosinophils and lymphocytes into the bronchoalveolar lavage (BAL) fluid and decreased inflammation in the lung tissues [2].
  • Selective decreases of alpha4+ T cells in the BAL fluid after PS/2 or MK2 treatment were coupled with changes in CD8+, CD11a, and CD62L expression [2].
 

Anatomical context of Mvk

  • T cells and eosinophils in BAL fluid from mice treated with PS/2 or MK2 were phenotypically different from controls [2].

References

  1. Investigation of invariant serine/threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site implicated in human inherited disease. Cho, Y.K., Ríos, S.E., Kim, J.J., Miziorko, H.M. J. Biol. Chem. (2001) [Pubmed]
  2. Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1. Chin, J.E., Hatfield, C.A., Winterrowd, G.E., Brashler, J.R., Vonderfecht, S.L., Fidler, S.F., Griffin, R.L., Kolbasa, K.P., Krzesicki, R.F., Sly, L.M., Staite, N.D., Richards, I.M. Am. J. Physiol. (1997) [Pubmed]
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