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Gene Review:

hlyB - hemolysin B

Escherichia coli O157:H7 str. Sakai

Sugamata, Y. et al., Spengler, G. et al.

Sugamata, Shiba,

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Disease relevance of hlyB

Improved secretory production of recombinant proteins by random mutagenesis of hlyB, an alpha-hemolysin transporter from Escherichia coli [1].

High impact information on hlyB

We aimed to establish an efficient Hly secretory expression system by random mutagenesis of hlyB and hlyD [1].
Lactose fermentation of E. coli or hemolysin B transporter expressed by the plasmids that carry these respective genes could be readily obviated by heterocyclic compounds that readily bind to plasmid DNA [2].

References

Improved secretory production of recombinant proteins by random mutagenesis of hlyB, an alpha-hemolysin transporter from Escherichia coli. Sugamata, Y., Shiba, T. Appl. Environ. Microbiol. (2005) [Pubmed]
The mechanism of plasmid curing in bacteria. Spengler, G., Molnár, A., Schelz, Z., Amaral, L., Sharples, D., Molnár, J. Current drug targets. (2006) [Pubmed]

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