The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Mylpf  -  myosin light chain, phosphorylatable, fast...

Mus musculus

Synonyms: 2410014J02Rik, Fast skeletal myosin light chain 2, MLC-2, MLC2F, Mlc2, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Mylpf

  • However, when BC3H1 cells differentiate in response to incubation in serum-deprived medium or upon approaching confluence, they express TnT as well as sarcomeric muscle isoforms of MHC, MLC 2 and 3, alpha-Tm, and alpha-actin [1].
  • By 11.5 d.p.c., all three hybridization signals colocalized in most extramyotomal muscle-forming regions, with the exception of the diaphragm and the hindlimb buds, where only few cells expressed MLC2 and more cells expressed MyoD1 than myogenin [2].
  • The fast skeletal muscle myosin light chain 2 (MLC2) gene is expressed specifically in skeletal muscles of newborn and adult mice, and has no detectable sequence homology with any of the other MLC genes including the slow cardiac MLC2 gene [2].
  • The expression of the fast skeletal muscle MLC2 gene during early mouse embryogenesis was studied by in situ hybridization [2].
  • MLC2 transcripts were first detected 9.5 d.p.c. in the myotomal regions of rostral somites, already expressing myogenin [2].
 

Biological context of Mylpf

 

Anatomical context of Mylpf

  • Here, we demonstrate that either transient or stable expression of MyoD in otherwise nonpermissive C3H10T1/2 fibroblast cells can promote the expression of MLC-2/CAT [5].
 

Other interactions of Mylpf

  • Third, that the exogenous MyoD1 transactivates the endogenous myogenin and MLC2 genes in ES cells [6].
  • Deletion and site-specific mutation analysis demonstrate that the MEF-2 site (Element B) in the MLC-2 promoter is the target of activation by MyoD [5].

References

  1. The expression of sarcomeric muscle-specific contractile protein genes in BC3H1 cells: BC3H1 cells resemble skeletal myoblasts that are defective for commitment to terminal differentiation. Taubman, M.B., Smith, C.W., Izumo, S., Grant, J.W., Endo, T., Andreadis, A., Nadal-Ginard, B. J. Cell Biol. (1989) [Pubmed]
  2. The expression of the regulatory myosin light chain 2 gene during mouse embryogenesis. Faerman, A., Shani, M. Development (1993) [Pubmed]
  3. Proteomic analysis of fast and slow muscles from normal and kyphoscoliotic mice using protein arrays, 2-DE and MS. Le Bihan, M.C., Hou, Y., Harris, N., Tarelli, E., Coulton, G.R. Proteomics (2006) [Pubmed]
  4. Ectopic expression of MyoD1 in mice causes prenatal lethalities. Faerman, A., Pearson-White, S., Emerson, C., Shani, M. Dev. Dyn. (1993) [Pubmed]
  5. Transactivation of cardiac MLC-2 promoter by MyoD in 10T1/2 fibroblast cells is independent of E-box requirement but depends upon new proteins that recognize MEF-2 site. Goswami, S.K., Siddiqui, M.A. Cell. Mol. Biol. Res. (1995) [Pubmed]
  6. The consequences of a constitutive expression of MyoD1 in ES cells and mouse embryos. Shani, M., Faerman, A., Emerson, C.P., Pearson-White, S., Dekel, I., Magal, Y. Symp. Soc. Exp. Biol. (1992) [Pubmed]
 
WikiGenes - Universities