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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

fat-7  -  Protein FAT-7

Caenorhabditis elegans

 
 
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High impact information on fat-7

  • Knockdown of mdt-15 by RNA interference (RNAi) prevented fasting-induced mRNA accumulation of NHR-49 targets in vivo, and fasting-independent expression of other NHR-49 target genes, including two FA-Delta9-desaturases (fat-5, fat-7) [1].
  • The predicted protein is highly homologous both to the cloned plant genes with similar function and to the published sequence of the C. elegans omega-3 fatty acid desaturase [2].

References

  1. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Taubert, S., Van Gilst, M.R., Hansen, M., Yamamoto, K.R. Genes Dev. (2006) [Pubmed]
  2. Identification and characterization of an animal delta(12) fatty acid desaturase gene by heterologous expression in Saccharomyces cerevisiae. Peyou-Ndi, M.M., Watts, J.L., Browse, J. Arch. Biochem. Biophys. (2000) [Pubmed]
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