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Gene Review:

H14N18.4 - Protein H14N18.4

Caenorhabditis elegans

Lobos, E. et al., Lobos, E. et al., Adcock, H.J. et al.

Lobos, Nutman, Hothersall, Moncada,

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Disease relevance of transpeptidase

A major allergen of the lymphatic filarial nematode Brugia malayi, a homologue of gamma-glutamyl transpeptidase (gamma-GT), is involved in the pathology of tropical pulmonary eosinophilia (TPE) through its potent allergenicity and the induction of antibodies against the host pulmonary epithelium [1].
Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity [1].

High impact information on transpeptidase

RESULTS: The predicted protein is a homolog of the entire precursor of the gamma-glutamyl transpeptidase (gamma-GT), a key enzyme in the synthesis and degradation of glutathione [2].
A major allergen of lymphatic filarial nematodes is a parasite homolog of the gamma-glutamyl transpeptidase [2].
Each species was screened for gamma-glutamyl transpeptidase activity and transaminase activity towards L-aspartate, L-alanine, L-albizziin and L-phenylalanine [3].

References

Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity. Lobos, E., Nutman, T.B., Hothersall, J.S., Moncada, S. Infect. Immun. (2003) [Pubmed]
A major allergen of lymphatic filarial nematodes is a parasite homolog of the gamma-glutamyl transpeptidase. Lobos, E., Zahn, R., Weiss, N., Nutman, T.B. Mol. Med. (1996) [Pubmed]
Cysteine conjugate beta-lyase activity in three species of parasitic helminth. Adcock, H.J., Brophy, P.M., Teesdale-Spittle, P.H., Buckberry, L.D. Int. J. Parasitol. (1999) [Pubmed]

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AgaP_AGAP000853	Anopheles gambiae str. PEST
GGT2	Arabidopsis thaliana
GGT4	Arabidopsis thaliana
GGT1	Arabidopsis thaliana
AGOS_AAR144W	Ashbya gossypii ATCC 10895
GGT1	Bos taurus
Y7A9A.1	Caenorhabditis elegans
C53D5.5	Caenorhabditis elegans
T03D8.6	Caenorhabditis elegans
GGT1	Canis lupus familiaris
ggt1a	Danio rerio
ggt1b	Danio rerio
CG4829	Drosophila melanogaster
GGT1	Gallus gallus
GGT1	Homo sapiens
KLLA0C05236g	Kluyveromyces lactis NRRL Y-1140
GGT2	Macaca mulatta
MGG_03882	Magnaporthe oryzae 70-15
Ggt1	Mus musculus
NCU01753	Neurospora crassa OR74A
GGT1	Pan troglodytes
Ggt1	Rattus norvegicus
ECM38	Saccharomyces cerevisiae S288c
ggt1	Schizosaccharomyces pombe 972h-
ggt2	Schizosaccharomyces pombe 972h-
ggt1	Xenopus (Silurana) tropicalis

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