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Gene Review:

hmp-1 - Protein HMP-1

Caenorhabditis elegans

Raich, W.B. et al., Costa, M. et al., Simske, J.S. et al., Pettitt, J. et al., Hoier, E.F. et al.

Pettitt, Cox, Broadbent, Flett, Hardin, Costa, Raich, Agbunag, Leung, Hardin, Priess, Simske, Köppen, Sims, Hodgkin, Yonkof, Hardin,

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High impact information on alpha-catenin

In this process, APR-1 may act in a Cadherin/alpha-Catenin/beta-Catenin complex as a component of adherens junctions [1].
These results suggest that VAB-9 regulates interactions between the cytoskeleton and the adherens junction downstream of or parallel to alpha-catenin and/or beta-catenin [2].
However, jac-1(RNAi) does increase the severity and penetrance of morphogenetic defects caused by a hypomorphic mutation in the hmp-1/alpha-catenin gene [3].
CONCLUSIONS: We propose that 'filopodial priming' - prealignment of bundled actin in filopodia combined with the rapid recruitment of alpha-catenin from cytoplasmic reserves at sites of filopodial contact - accounts for the rapid rate of sealing of the embryonic epidermis of C. elegans [4].
Rapid recruitment of alpha-catenin to sites of filopodial contact between contralateral migrating epithelial cells, concomitant with clearing of cytoplasmic alpha-catenin, resulted in formation of nascent junctions; this preceded the formation of mature junctions [4].

Biological context of alpha-catenin

The sequences of the predicted HMP-1, HMP-2, and HMR-1 proteins are related to the cell adhesion proteins alpha-catenin, beta-catenin/Armadillo, and classical cadherin, respectively [5].

References

The Caenorhabditis elegans APC-related gene apr-1 is required for epithelial cell migration and Hox gene expression. Hoier, E.F., Mohler, W.A., Kim, S.K., Hajnal, A. Genes Dev. (2000) [Pubmed]
The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske, J.S., Köppen, M., Sims, P., Hodgkin, J., Yonkof, A., Hardin, J. Nat. Cell Biol. (2003) [Pubmed]
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. Pettitt, J., Cox, E.A., Broadbent, I.D., Flett, A., Hardin, J. J. Cell Biol. (2003) [Pubmed]
Rapid epithelial-sheet sealing in the Caenorhabditis elegans embryo requires cadherin-dependent filopodial priming. Raich, W.B., Agbunag, C., Hardin, J. Curr. Biol. (1999) [Pubmed]
A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo. Costa, M., Raich, W., Agbunag, C., Leung, B., Hardin, J., Priess, J.R. J. Cell Biol. (1998) [Pubmed]

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alpha-Cat	Drosophila melanogaster
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ctnna2	Xenopus (Silurana) tropicalis

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