Gene Review:
sma-1 - Protein SMA-1
Caenorhabditis elegans
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High impact information on sma-1
- SMA-1 is required to maintain the association between actin and the apical membrane; sma-1 mutant embryos fail to elongate because actin, which provides the driving force for cell shape change, dissociates from the apical membrane skeleton during morphogenesis [1].
Other interactions of sma-1
- Analysis of sma-1 expression constructs and mutant strains indicates SMA-1 maintains the association between actin and the apical membrane via interactions at its N-terminus and this activity is independent of alpha-spectrin [1].
References
- SMA-1 spectrin has essential roles in epithelial cell sheet morphogenesis in C. elegans. Praitis, V., Ciccone, E., Austin, J. Dev. Biol. (2005) [Pubmed]
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