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Gene Review

unc-51  -  Protein UNC-51

Caenorhabditis elegans

 
 
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High impact information on unc-51

  • The unc-14 gene encodes a novel protein of 665 amino acids, and is coexpressed with the unc-51 gene in the cell bodies and axons of almost all neurons including DD/VD and hermaphrodite-specific neurons [1].
  • We cloned the unc-51 gene previously and predicted that it encodes a novel serine/threonine protein kinase [1].
  • Expression of an unc-51/lacZ fusion gene was observed in many neurons at all stages [2].
  • We propose that protein phosphorylation by the unc-51 product is important for axonal elongation and possibly for axonal guidance [2].
  • The wild-type unc-51 gene, which rescued the mutant phenotypes, encodes a novel serine/threonine kinase of 856 amino acids [2].
 

Associations of unc-51 with chemical compounds

  • Here we observed that, in unc-51 and unc-14 mutants, UNC-5, the receptor for axon-guidance protein Netrin/UNC-6, abnormally localized in neuronal cell bodies [3].

References

 
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