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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dlg-1  -  Protein DLG-1

Caenorhabditis elegans

 
 
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High impact information on dlg-1

  • Mutations in vab-9 enhance adhesion defects through functional loss of the cell junction genes apical junction molecule 1 (ajm-1) and discs large 1 (dlg-1), suggesting that VAB-9 is involved in cell adhesion [1].
  • Here we analyse the roles of C. elegans genes let-413 and dlg-1, a homologue of Drosophila lethal discs large, in the assembly of the C. elegans apical junction (CeAJ), and provide the first characterisation of this structure [2].
  • We have identified dlg-1 as an essential gene in an RNA interference screen against C. elegans homologues of genes encoding proteins involved in tight or septate junction formation [2].
  • Removal of dlg-1, ajm-1, or hmp-1 function has little effect on the overall position or continuity of the terminal web IFB-2-containing layer [3].
  • Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large [4].
 

Anatomical context of dlg-1

  • Loss of dlg-1 activity differentially affects localisation of proteins normally enriched apically to the zonula adherens [4].

References

  1. The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske, J.S., Köppen, M., Sims, P., Hodgkin, J., Yonkof, A., Hardin, J. Nat. Cell Biol. (2003) [Pubmed]
  2. Assembly of C. elegans apical junctions involves positioning and compaction by LET-413 and protein aggregation by the MAGUK protein DLG-1. McMahon, L., Legouis, R., Vonesch, J.L., Labouesse, M. J. Cell. Sci. (2001) [Pubmed]
  3. The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413. Bossinger, O., Fukushige, T., Claeys, M., Borgonie, G., McGhee, J.D. Dev. Biol. (2004) [Pubmed]
  4. Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large. Bossinger, O., Klebes, A., Segbert, C., Theres, C., Knust, E. Dev. Biol. (2001) [Pubmed]
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