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Gene Review

Nktr  -  natural killer tumor recognition sequence

Mus musculus

Synonyms: 5330401F18Rik, D9Wsu172e, NK-TR protein, NK-tumor recognition protein, Natural-killer cells cyclophilin-related protein
 
 
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High impact information on Nktr

  • Identification of the clones as members of the NK lineage was based on large granular morphology, expression of NK-TR and absence of TCR gene rearrangement [1].
  • A 10-kb intron was found to remain in mRNAs produced in bone marrow, and an alternative exon capable of interrupting the Nktr open reading frame was found in immature NK cells [2].
  • We have cloned and determined the structure of the 5' region of the mouse Nktr gene located on the distal end of mouse chromosome 9 [2].
  • The region of the Nktr gene cloned in this study spans 25 kb and contains the promoter, eight exons, and a single alternative exon [2].
  • The Nktr promoter region has features that are typical of a housekeeping gene, including high G + C content, high frequency of CpG dinucleotides, and a lack of canonical TATAA and CCAAT boxes [2].
 

Anatomical context of Nktr

References

  1. Phenotypic and functional characterization of a panel of cytotoxic murine NK cell clones that are heterogeneous in their enhancement of Ig secretion in vitro. Vos, Q., Ortaldo, J.R., Conan-Cibotti, M., Vos, M.D., Young, H.A., Anderson, S.K., Witherspoon, K., Prager, I., Snapper, C.M., Mond, J.J. Int. Immunol. (1998) [Pubmed]
  2. Characterization of the mouse Nktr gene and promoter. Simons-Evelyn, M., Young, H.A., Anderson, S.K. Genomics (1997) [Pubmed]
 
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