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Gene Review

hsp-3  -  Protein HSP-3

Caenorhabditis elegans

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High impact information on hsp-3

  • We compared portions of the hsp-3 homologs, two grp 78-like genes, from C. elegans and C. briggsae and detected regions of DNA identity in the coding region, the 5' flanking DNAs, and the introns [1].
  • We show that this compensatory regulation is specific for ER chaperones, not dependent on RNA interference, and required for maintaining viability in worms containing a deletion of the hsp-3 gene [2].


  1. Functional elements and domains inferred from sequence comparisons of a heat shock gene in two nematodes. Heschl, M.F., Baillie, D.L. J. Mol. Evol. (1990) [Pubmed]
  2. Compensatory regulation among ER chaperones in C. elegans. Kapulkin, V., Hiester, B.G., Link, C.D. FEBS Lett. (2005) [Pubmed]
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