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Gene Review:

pept-1 - Protein PEPT-1

Caenorhabditis elegans

Meissner, B. et al., McElwee, J.J. et al., Nehrke, K.

Nehrke,

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High impact information on opt-2

In addition, we observed down-regulation of genes linked to nutrient uptake, including nhx-2 and pep-2 [1].
The pep-2 mutant enhances the developmental and longevity phenotypes of daf-2, resulting, among other effects, in a pronounced increase in adult life span [2].
Moreover, all aspects of a weak let-363/TOR RNA interference phenotype are intensified by pep-2 deletion, indicating that pep-2 function upstream of TOR-mediated nutrient sensing [2].

Biological context of opt-2

Gene inactivation of opt-2 led to a phenotype resembling that of nhx-2, although not as severe [3].

References

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance. McElwee, J.J., Schuster, E., Blanc, E., Thomas, J.H., Gems, D. J. Biol. Chem. (2004) [Pubmed]
Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans. Meissner, B., Boll, M., Daniel, H., Baumeister, R. J. Biol. Chem. (2004) [Pubmed]
A reduction in intestinal cell pHi due to loss of the Caenorhabditis elegans Na+/H+ exchanger NHX-2 increases life span. Nehrke, K. J. Biol. Chem. (2003) [Pubmed]

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AgaP_AGAP010383	Anopheles gambiae str. PEST
PTR2	Arabidopsis thaliana
SLC15A1	Bos taurus
pept-2	Caenorhabditis elegans
SLC15A1	Canis lupus familiaris
slc15a1a	Danio rerio
slc15a1b	Danio rerio
CG2930	Drosophila melanogaster
SLC15A1	Gallus gallus
SLC15A1	Homo sapiens
KLLA0E12915g	Kluyveromyces lactis NRRL Y-1140
SLC15A1	Macaca mulatta
Slc15a1	Mus musculus
Os03g0719900	Oryza sativa Japonica Group
SLC15A1	Pan troglodytes
Slc15a1	Rattus norvegicus
PTR2	Saccharomyces cerevisiae S288c
SPBC13A2.04c	Schizosaccharomyces pombe 972h-
slc15a1	Xenopus (Silurana) tropicalis

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