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Gene Review

acr-3  -  Protein ACR-3

Caenorhabditis elegans

 
 
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High impact information on acr-3

  • Mutations have been found in multiple classes of nicotinic acetylcholine receptor genes, excitatory and inhibitory glutamate receptor genes, and candidate gap junction genes, allowing their function to be studied in vivo [1].
  • Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans [2].
  • Potential acetylcholine receptor (AChR) mutants of the nematode are selectable by resistance to the neurotoxic drug levamisole, a probable cholinergic agonist [3].
  • 1. We have investigated activation and block, by the tetrahydropyrimidine anthelmintic, morantel, of nicotinic-acetylcholine receptor (AChR) currents in membrane vesicles isolated from somatic muscle cells of the nematode parasite Ascaris suum [4].
  • The simple nervous system of C. elegans possesses one of the largest nicotinic acetylcholine receptor gene families known for any organism and a combination of genetic, microarray, physiological and reporter gene expression studies have added greatly to our understanding of the components of nematode muscle and neuronal nAChR subtypes [5].
 

Biological context of acr-3

  • Studies on one of these loci, acr-2, are described; acr-2 is located between sup-7 and unc-6 on the X chromosome [6].
 

Anatomical context of acr-3

 

Associations of acr-3 with chemical compounds

  • Morantel in the pipette (6 nM to 600 microM), activated single nicotinic AChR currents [4].
  • Similar analyses were performed on a phosphoenolpyruvate carboxykinase gene and a nicotinic acetylcholine receptor subunit gene [8].
 

Other interactions of acr-3

  • Analysis of the acr-2 genomic DNA revealed the existence of another potential nAChR subunit gene, acr-3, in the same orientation, only 281 bp downstream of acr-2 [7].
 

Analytical, diagnostic and therapeutic context of acr-3

  • The molecular cloning and functional co-expression of a novel nicotinic acetylcholine receptor (nAChR) non-alpha subunit gene, acr-3, is described [7].
  • A cDNA containing the entire acr-3 coding sequence was isolated by RT-PCR and sequenced [7].

References

  1. Signal transduction in the Caenorhabditis elegans nervous system. Bargmann, C.I., Kaplan, J.M. Annu. Rev. Neurosci. (1998) [Pubmed]
  2. Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans. Jones, A.K., Sattelle, D.B. Bioessays (2004) [Pubmed]
  3. Cholinergic receptor mutants of the nematode Caenorhabditis elegans. Lewis, J.A., Elmer, J.S., Skimming, J., McLafferty, S., Fleming, J., McGee, T. J. Neurosci. (1987) [Pubmed]
  4. Activation and cooperative multi-ion block of single nicotinic-acetylcholine channel currents of Ascaris muscle by the tetrahydropyrimidine anthelmintic, morantel. Evans, A.M., Martin, R.J. Br. J. Pharmacol. (1996) [Pubmed]
  5. Contributions from Caenorhabditis elegans functional genetics to antiparasitic drug target identification and validation: nicotinic acetylcholine receptors, a case study. Brown, L.A., Jones, A.K., Buckingham, S.D., Mee, C.J., Sattelle, D.B. Int. J. Parasitol. (2006) [Pubmed]
  6. Molecular cloning and functional co-expression of a Caenorhabditis elegans nicotinic acetylcholine receptor subunit (acr-2). Squire, M.D., Tornøe, C., Baylis, H.A., Fleming, J.T., Barnard, E.A., Sattelle, D.B. Recept. Channels (1995) [Pubmed]
  7. ACR-3, a Caenorhabditis elegans nicotinic acetylcholine receptor subunit. Molecular cloning and functional expression. Baylis, H.A., Matsuda, K., Squire, M.D., Fleming, J.T., Harvey, R.J., Darlison, M.G., Barnard, E.A., Sattelle, D.B. Recept. Channels (1997) [Pubmed]
  8. Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins. Blackhall, W.J., Prichard, R.K., Beech, R.N. Mol. Biochem. Parasitol. (2003) [Pubmed]
 
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