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Gene Review

Nkx2-9  -  NK2 homeobox 9

Mus musculus

Synonyms: Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.8, Homeobox protein Nkx-2.9, Nkx-2.9, Nkx2-8, ...
 
 
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High impact information on Nkx2-9

 

Biological context of Nkx2-9

  • We previously reported close physical linkage between Pax9 and Nkx2-9 in the human, mouse, and pufferfish (Fugu rubripes) genomes [2].
  • Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny [2].
  • We identified two regions including conserved noncoding sequences that possessed specific enhancer activities for expression of Pax9 in the medial nasal process and of Nkx2-9 in the ventral neural tube [2].
  • Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS [3].
  • During embryonic development, Nkx2-9-expressing cells shift from the presumptive floor plate into a more dorsolateral position of the neuroectoderm and later become limited to the ventricular zone [3].
 

Anatomical context of Nkx2-9

  • Our results suggest that specification of V3 interneurons in the posterior CNS does not require Nkx2.9, most probably because of functional redundancy with the co-expressed Nkx2.2 protein [1].
 

Other interactions of Nkx2-9

  • Nkx2-9 expression overlaps with that of Nkx2-2 but is generally broader [3].

References

  1. Targeted disruption of the homeobox gene Nkx2.9 reveals a role in development of the spinal accessory nerve. Pabst, O., Rummelies, J., Winter, B., Arnold, H.H. Development (2003) [Pubmed]
  2. Identification of Cis-regulatory elements in the mouse Pax9/Nkx2-9 genomic region: implication for evolutionary conserved synteny. Santagati, F., Abe, K., Schmidt, V., Schmitt-John, T., Suzuki, M., Yamamura, K., Imai, K. Genetics (2003) [Pubmed]
  3. Nkx2-9 is a novel homeobox transcription factor which demarcates ventral domains in the developing mouse CNS. Pabst, O., Herbrand, H., Arnold, H.H. Mech. Dev. (1998) [Pubmed]
 
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