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Gene Review:

vav-1 - Protein VAV-1

Caenorhabditis elegans

Yoo, A.S. et al., Norman, K.R. et al.

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High impact information on vav-1

Here, we show that the C. elegans Rho/Rac-family guanine nucleotide exchange factor, VAV-1, which is homologous to the mammalian Vav proto-oncogene, has a crucial role in all three behaviors. vav-1 mutants die as larvae because VAV-1 function is required in the pharynx for synchronous contraction of the musculature [1].
Our results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in the presumptive 2 degrees VPCs [2].

Biological context of vav-1

We also identify vav-1, the ortholog of the Vav oncogene, as a target of mir-61, and show that down-regulation of VAV-1 promotes lin-12 activity in specifying the 2 degrees fate [2].

References

The Rho/Rac-family guanine nucleotide exchange factor VAV-1 regulates rhythmic behaviors in C. elegans. Norman, K.R., Fazzio, R.T., Mellem, J.E., Espelt, M.V., Strange, K., Beckerle, M.C., Maricq, A.V. Cell (2005) [Pubmed]
LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Yoo, A.S., Greenwald, I. Science (2005) [Pubmed]

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vav3b	Danio rerio
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