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Gene Review

nhr-25  -  Protein NHR-25

Caenorhabditis elegans

 
 
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High impact information on nhr-25

  • In a subset of Pn.p cells, called vulval precursor cells, nhr-25 acts collaboratively with the lin-39 Hox gene in regulating vulval cell differentiation [1].
  • Additionally, our data suggest that nhr-25 may also function with another Hox gene, nob-1, during embryogenesis [1].
  • Impairment of nhr-25 activity leads to severe phenotypes in embryos and many postembryonic tissues [1].
  • Adults with reduced levels of mir-84 and let-7 express genes characteristic of larval molting as they initiate a supernumerary molt. mir-84 and let-7 promote exit from the molting cycle by regulating targets in the heterochronic pathway and also nhr-23 and nhr-25, genes encoding conserved nuclear hormone receptors essential for larval molting [2].
  • Unexpectedly, the lack of cell-cell contacts does not prevent a unique seam cell to produce a neuroblast, even though a homeotic gene (mab-5) that normally prevents the neuroblast commitment is ectopically expressed in the absence of nhr-25 function [3].
 

Biological context of nhr-25

 

Anatomical context of nhr-25

  • nhr-25, the Caenorhabditis elegans ortholog of ftz-f1, is required for epidermal and somatic gonad development [5].
  • The hypodermal expression of acn-1 appears to be controlled by nhr-23 and nhr-25, two nuclear hormone receptors known to regulate molting in C. elegans. acn-1(RNAi) causes arrest of larval development because of a molting defect, a protruding vulva in adult hermaphrodites, severely disrupted alae, and an incomplete seam syncytium [6].
 

Regulatory relationships of nhr-25

  • Although some seam cells retain the ability to fuse at the final larval stage, the resulting syncytium shows gaps and bifurcations, translating into anomalies in cuticular ridges (alae) produced by the syncytium. nhr-25 RNAi markedly enhances branching of the alae caused by a mutant cuticular collagen gene rol-6 [3].
 

Analytical, diagnostic and therapeutic context of nhr-25

References

 
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