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Gene Review

unc-3  -  Protein UNC-3

Caenorhabditis elegans

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High impact information on unc-3

  • The mutations also affect some food-related functions, including growth rate, the expulsion step of defecation behavior, and the regulation of the dauer larva (a nonfeeding, special third-stage larva) formation in the unc-3 (Olf-1/EBF homolog) background [1].
  • We demonstrate that CeO/E is the product of the unc-3 gene, mutations in which cause defects in the axonal outgrowth of motor neurons, as well as defects in dauer formation, a process requiring chemosensory inputs [2].
  • Epistasis experiments place unc-64 and unc-31 at a different position in the dauer pathway from unc-3 [3].
  • Although originally isolated because of its uncoordinated behavior, this strain was subsequently shown to harbor mutations in two genes; one in the previously identified gene unc-3, accounting for its behavior, and one in a newly identified gene, ace-1, accounting for its selective acetylcholinesterase deficiency [4].


  1. An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans. Take-Uchi, M., Kawakami, M., Ishihara, T., Amano, T., Kondo, K., Katsura, I. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  2. unc-3, a gene required for axonal guidance in Caenorhabditis elegans, encodes a member of the O/E family of transcription factors. Prasad, B.C., Ye, B., Zackhary, R., Schrader, K., Seydoux, G., Reed, R.R. Development (1998) [Pubmed]
  3. Dauer formation induced by high temperatures in Caenorhabditis elegans. Ailion, M., Thomas, J.H. Genetics (2000) [Pubmed]
  4. An acetylcholinesterase-deficient mutant of the nematode Caenorhabditis elegans. Johnson, C.D., Duckett, J.G., Culotti, J.G., Herman, R.K., Meneely, P.M., Russell, R.L. Genetics (1981) [Pubmed]
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