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Gene Review

Npy2r  -  neuropeptide Y receptor Y2

Mus musculus

Synonyms: NPY-Y2 receptor, NPY2-R, Neuropeptide Y receptor type 2, Y2 receptor
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Disease relevance of Npy2r


Psychiatry related information on Npy2r

  • We investigated the effects of NPY Y2 receptor deletion (Y2(-/-)) in mice on visual attention and response control using the five-choice serial reaction time (5-CSRT) task in which accuracy of detection of a brief visual stimulus across five spatial locations may serve as a valid behavioural index of attentional functioning [3].
  • These data provide further evidence that modulators of the NPY Y2 receptor subtype are drug targets for the treatment of anxiety and mood disorders in human subjects [4].

High impact information on Npy2r

  • Our comparisons strongly suggest that the tight cluster of NPY1R, NPY2R, and NPY5R on human chromosome 4 (HSA4) represents the ancestral configuration, whereas the porcine cluster has been split by two inversions on SSC8 [5].
  • Both the NPY Y1 receptor agonist [Leu31,Pro34]-NPY and NPY Y2 receptor agonist NPY(13-36) mimicked the effect of NPY on the number of transported particles [6].
  • To determine whether deletion of individual Y-receptors results in altered mRNA expression and/or binding toward other Y-receptor types, we applied in-situ hybridization and radioligand-binding studies on brain slices of Npy1r-, Npy2r- or Npy5r-knockout mice [7].
  • We have now assigned Npy1r and Npy2r to conserved linkage groups on mouse Chr 8 and Chr 3, respectively, which correspond to the distal region of human chromosome 4q [8].
  • Increased levels of NPY Y2 receptor and polo-like kinase and decreased levels of endothelin receptor type b in L mice are examples of novel gene expression changes not previously identified [9].

Biological context of Npy2r

  • Previous studies demonstrated that NPY Y2 receptor knockout (KO) mice display an anxiolytic- and antidepressant-like phenotype compared with control animals [4].
  • Analysis of the predicted amino-acid sequence indicates that the polypeptide encoded by this cDNA is 94% homologous to the human NPY-Y2 receptor [2].

Anatomical context of Npy2r


Associations of Npy2r with chemical compounds

  • Here, we examined the effects of a selective NPY-Y2 receptor antagonist, BIIE0246, on operant responding for ethanol in a sweetened solution, or the sweetened solution without ethanol, during 30 min sessions of free choice between the two [10].
  • In control mice in the presence of the beta-adrenoceptor antagonist propranolol (1 mg/kg), and 1 micromol/kg BIIE0426 (an NPY Y2 receptor antagonist) the deltaPI was 57+/-3% with a half time to recovery of 2.5+/-0.5 min [11].

Other interactions of Npy2r

  • Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropeptide Y receptors, have been mapped by interspecific backcross analysis [8].

Analytical, diagnostic and therapeutic context of Npy2r


  1. Attenuation of hypercholesterolemia and hyperglycemia in ob/ob mice by NPY Y2 receptor ablation. Naveilhan, P., Svensson, L., Nyström, S., Ekstrand, A.J., Ernfors, P. Peptides (2002) [Pubmed]
  2. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Nakamura, M., Aoki, Y., Hirano, D. Biochim. Biophys. Acta (1996) [Pubmed]
  3. Reduced attention and increased impulsivity in mice lacking NPY Y2 receptors: relation to anxiolytic-like phenotype. Greco, B., Carli, M. Behav. Brain Res. (2006) [Pubmed]
  4. Emotional behavior in aged neuropeptide Y (NPY) Y2 knockout mice. Carvajal, C., Dumont, Y., Herzog, H., Quirion, R. J. Mol. Neurosci. (2006) [Pubmed]
  5. Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Wraith, A., Törnsten, A., Chardon, P., Harbitz, I., Chowdhary, B.P., Andersson, L., Lundin, L.G., Larhammar, D. Genome Res. (2000) [Pubmed]
  6. Neuropeptide Y inhibits axonal transport of particles in neurites of cultured adult mouse dorsal root ganglion cells. Hiruma, H., Saito, A., Kusakabe, T., Takenaka, T., Kawakami, T. J. Physiol. (Lond.) (2002) [Pubmed]
  7. Y1-receptors regulate the expression of Y2-receptors in distinct mouse forebrain areas. Wittmann, W., Loacker, S., Kapeller, I., Herzog, H., Schwarzer, C. Neuroscience (2005) [Pubmed]
  8. Neuropeptide Y receptor genes on human chromosome 4q31-q32 map to conserved linkage groups on mouse chromosomes 3 and 8. Lutz, C.M., Frankel, W.N., Richards, J.E., Thompson, D.A. Genomics (1997) [Pubmed]
  9. Gene array profiling of large hypothalamic CNS regions in lactating and randomly cycling virgin mice. Gammie, S.C., Hasen, N.S., Awad, T.A., Auger, A.P., Jessen, H.M., Panksepp, J.B., Bronikowski, A.M. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  10. Blockade of central neuropeptide Y (NPY) Y2 receptors reduces ethanol self-administration in rats. Thorsell, A., Rimondini, R., Heilig, M. Neurosci. Lett. (2002) [Pubmed]
  11. Galanin modulates cholinergic neurotransmission in the heart. Potter, E.K., Smith-White, M.A. Neuropeptides (2005) [Pubmed]
  12. Characterization of neuropeptide Y2 receptor protein expression in the mouse brain. I. Distribution in cell bodies and nerve terminals. Stani??, D., Brumovsky, P., Fetissov, S., Shuster, S., Herzog, H., H??kfelt, T. J. Comp. Neurol. (2006) [Pubmed]
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