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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

unc-75  -  Protein UNC-75

Caenorhabditis elegans

 
 
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High impact information on unc-75

  • Furthermore, syd-9 functions in parallel with unc-75 (unc, uncoordinated), the C. elegans homologue of the CELF/BrunoL family protein that regulates mRNA alternative splicing and processing, and is also required specifically for synaptic transmission [1].
  • We found that human orthologs of UNC-75, whose splicing activity has recently been documented in vitro, are expressed nearly exclusively in brain and when expressed in C. elegans, rescue unc-75 mutant phenotypes and localize to subnuclear puncta [2].
  • We show that unc-75 encodes an RRM domain-containing RNA binding protein that is exclusively expressed in the nervous system and neurosecretory gland cells [2].
  • By inducing genetic markers on this crossover suppressor and establishing the gene order in the homozygote, hIn1(I) was demonstrated to be the first genetically proven inversion in Caenorhabditis elegans. hIn1(I) extensively suppresses recombination in heterozygotes in the right arm of chromosome I from unc-75 to unc-54 [3].

References

  1. The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission. Wang, Y., Gracheva, E.O., Richmond, J., Kawano, T., Couto, J.M., Calarco, J.A., Vijayaratnam, V., Jin, Y., Zhen, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission. Loria, P.M., Duke, A., Rand, J.B., Hobert, O. Curr. Biol. (2003) [Pubmed]
  3. The meiotic behavior of an inversion in Caenorhabditis elegans. Zetka, M.C., Rose, A.M. Genetics (1992) [Pubmed]
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