The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

Slc22a6  -  solute carrier family 22 (organic anion...

Mus musculus

Synonyms: Kidney-specific transport protein, NKT, Nkt, Novel kidney transcript, Oat1, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of Slc22a6

  • Here, we show that SAP, encoded by the SH2D1A gene locus, also has a crucial role during the development of NKT cells, a lymphocyte subset with immunoregulatory functions in response to infection, cancer and autoimmune disease [1].
  • Conditional deletion of the Mttp gene in hepatocytes is associated with a redistribution of CD1d expression, and Mttp-deleted mice are resistant to immunopathologies associated with invariant NKT cell-mediated hepatitis and colitis [2].
  • The absence of NKT cells may contribute to the phenotypes of SAP deficiency, including abnormal antiviral and antitumor immunity and hypogammaglobulinemia [1].
  • Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex [3].
  • Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection [4].
 

High impact information on Slc22a6

  • While evaluating the abnormalities in alphaGC-induced immune responses, we observed that Sh2d1a-/- animals lacked NKT cells in the thymus and peripheral organs [1].
  • Following stimulation with the NKT cell-specific agonist alpha-galactosyl ceramide (alphaGC), Sh2d1a-/- splenocytes did not produce cytokines or activate other lymphoid lineages in an NKT cell-dependent manner [1].
  • Furthermore, a female XLP carrier showed completely skewed X chromosome inactivation within NKT cells, but not T or B cells [1].
  • Seventeen individuals with X-linked lymphoproliferative disease (XLP), who harbored germline mutations in SH2D1A, also lacked NKT cells [1].
  • CD1d is a major histocompatibility complex (MHC) class I-related molecule that functions in glycolipid antigen presentation to distinct subsets of T cells that express natural killer receptors and an invariant T-cell receptor-alpha chain (invariant NKT cells) [2].
 

Chemical compound and disease context of Slc22a6

  • alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10 [5].
  • In this paper we characterized the Valpha14 NKT cell population following infection with Mycobacterium bovis bacillus Calmette-Guérin (BCG) [6].
  • Adoptive transfer of NKT cells pulsed with HCC-derived antigens (group A) and NKT cells from immunized donors (group E) resulted in complete disappearance of tumors within 4 weeks and attenuated weight loss (6.5% and 7% in groups A and E, respectively) [7].
  • CONCLUSIONS: Copaxone had class-II-restricted anti-inflammatory effect in our animal colitis model associated with CD4/NK/NKT/TH1/TH2 suppression [8].
 

Biological context of Slc22a6

  • NKT was mapped by linkage disequilibrium to mouse chromosome 19, the same site to which several mouse mutations localize, including that for osteochondrodystrophy (ocd) [9].
  • The NKT was characterized further with respect to its tissue distribution and its expression during kidney development [9].
  • Analysis of the deduced 546-amino acid protein sequence indicates that NKT is a unique gene product which shares a similar transmembrane domain hydropathy profile as well as transporter-specific amino acid motifs with a variety of bacterial and mammalian nutrient transporters [9].
  • Nevertheless, the overall homology of NKT to two recently cloned organic ion transport proteins (NLT and OCT-1) is significantly greater; together these three gene products may represent a new subgroup of transporters [9].
  • In addition to roles in T, NKT, and macrophage cell function, a new study indicates that SOCS1 modulates dendritic cell activation and may help prevent autoimmunity [10].
 

Anatomical context of Slc22a6

 

Associations of Slc22a6 with chemical compounds

  • In the kidney, NKT (OAT1), OCT1, and Roct transcripts appeared at midgestation, coinciding with proximal tubule differentiation, and gradually increased during nephron maturation [15].
  • Functional MTP, demonstrated by specific triglyceride transfer activity, is present in both mouse splenocytes and a CD1d-positive mouse NKT hybridoma [16].
  • Furthermore, thymic Vbeta7(+) Valpha14i NKT cells were preferentially selected in vitro in response to CD1d-dependent presentation of endogenous ligands or exogenously added self ligand isoglobotrihexosylceramide [17].
  • Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation [18].
  • Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance [19].
 

Analytical, diagnostic and therapeutic context of Slc22a6

  • Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney [9].
  • NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway [20].
  • Moreover, the adoptive transfer of NKT cells into CD1d-/- mice restored arthritis and reduced TGF-beta1 production [21].
  • Our study elucidates, for the first time, the crucial role of Gr-1+CD11b+ cells and the IFN-gamma they produce in islet graft rejection and suggests a novel approach to improving transplantation efficiency through the modulation of Valpha14 NKT cell function [13].
  • Additionally, animals with transferred A(2A)R(-/-) NKT cells are not protected from hepatic reperfusion injury by ATL146e [22].

References

  1. Regulation of NKT cell development by SAP, the protein defective in XLP. Nichols, K.E., Hom, J., Gong, S.Y., Ganguly, A., Ma, C.S., Cannons, J.L., Tangye, S.G., Schwartzberg, P.L., Koretzky, G.A., Stein, P.L. Nat. Med. (2005) [Pubmed]
  2. CD1d function is regulated by microsomal triglyceride transfer protein. Brozovic, S., Nagaishi, T., Yoshida, M., Betz, S., Salas, A., Chen, D., Kaser, A., Glickman, J., Kuo, T., Little, A., Morrison, J., Corazza, N., Kim, J.Y., Colgan, S.P., Young, S.G., Exley, M., Blumberg, R.S. Nat. Med. (2004) [Pubmed]
  3. Regulation of murine cerebral malaria pathogenesis by CD1d-restricted NKT cells and the natural killer complex. Hansen, D.S., Siomos, M.A., Buckingham, L., Scalzo, A.A., Schofield, L. Immunity (2003) [Pubmed]
  4. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Baron, J.L., Gardiner, L., Nishimura, S., Shinkai, K., Locksley, R., Ganem, D. Immunity (2002) [Pubmed]
  5. alpha/beta-T cell receptor (TCR)+CD4-CD8- (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. Hammond, K.J., Poulton, L.D., Palmisano, L.J., Silveira, P.A., Godfrey, D.I., Baxter, A.G. J. Exp. Med. (1998) [Pubmed]
  6. An anti-inflammatory role for V alpha 14 NK T cells in Mycobacterium bovis bacillus Calmette-Guérin-infected mice. Dieli, F., Taniguchi, M., Kronenberg, M., Sidobre, S., Ivanyi, J., Fattorini, L., Iona, E., Orefici, G., De Leo, G., Russo, D., Caccamo, N., Sireci, G., Di Sano, C., Salerno, A. J. Immunol. (2003) [Pubmed]
  7. Suppression of hepatocellular carcinoma by transplantation of ex-vivo immune-modulated NKT lymphocytes. Margalit, M., Shibolet, O., Klein, A., Elinav, E., Alper, R., Thalenfeld, B., Engelhardt, D., Rabbani, E., Ilan, Y. Int. J. Cancer (2005) [Pubmed]
  8. Amelioration of experimental colitis by Copaxone is associated with class-II-restricted CD4 immune blocking. Gur, C., Karussis, D., Golden, E., Doron, S., Ilan, Y., Safadi, R. Clin. Immunol. (2006) [Pubmed]
  9. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney. Lopez-Nieto, C.E., You, G., Bush, K.T., Barros, E.J., Beier, D.R., Nigam, S.K. J. Biol. Chem. (1997) [Pubmed]
  10. Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1. Starr, R., Hilton, D.J. Immunity (2003) [Pubmed]
  11. Murine CD1d-restricted T cell recognition of cellular lipids. Gumperz, J.E., Roy, C., Makowska, A., Lum, D., Sugita, M., Podrebarac, T., Koezuka, Y., Porcelli, S.A., Cardell, S., Brenner, M.B., Behar, S.M. Immunity (2000) [Pubmed]
  12. Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. Wei, D.G., Lee, H., Park, S.H., Beaudoin, L., Teyton, L., Lehuen, A., Bendelac, A. J. Exp. Med. (2005) [Pubmed]
  13. Valpha14 NK T cell-triggered IFN-gamma production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets. Yasunami, Y., Kojo, S., Kitamura, H., Toyofuku, A., Satoh, M., Nakano, M., Nabeyama, K., Nakamura, Y., Matsuoka, N., Ikeda, S., Tanaka, M., Ono, J., Nagata, N., Ohara, O., Taniguchi, M. J. Exp. Med. (2005) [Pubmed]
  14. NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs. Morris, E.S., MacDonald, K.P., Rowe, V., Banovic, T., Kuns, R.D., Don, A.L., Bofinger, H.M., Burman, A.C., Olver, S.D., Kienzle, N., Porcelli, S.A., Pellicci, D.G., Godfrey, D.I., Smyth, M.J., Hill, G.R. J. Clin. Invest. (2005) [Pubmed]
  15. Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct. Pavlova, A., Sakurai, H., Leclercq, B., Beier, D.R., Yu, A.S., Nigam, S.K. Am. J. Physiol. Renal Physiol. (2000) [Pubmed]
  16. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. Dougan, S.K., Salas, A., Rava, P., Agyemang, A., Kaser, A., Morrison, J., Khurana, A., Kronenberg, M., Johnson, C., Exley, M., Hussain, M.M., Blumberg, R.S. J. Exp. Med. (2005) [Pubmed]
  17. Cutting edge: influence of the TCR Vbeta domain on the selection of semi-invariant NKT cells by endogenous ligands. Schümann, J., Mycko, M.P., Dellabona, P., Casorati, G., MacDonald, H.R. J. Immunol. (2006) [Pubmed]
  18. Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. Giabbai, B., Sidobre, S., Crispin, M.D., Sanchez-Ruìz, Y., Bachi, A., Kronenberg, M., Wilson, I.A., Degano, M. J. Immunol. (2005) [Pubmed]
  19. Regulatory roles of NKT cells in the induction and maintenance of cyclophosphamide-induced tolerance. Iwai, T., Tomita, Y., Okano, S., Shimizu, I., Yasunami, Y., Kajiwara, T., Yoshikai, Y., Taniguchi, M., Nomoto, K., Yasui, H. J. Immunol. (2006) [Pubmed]
  20. NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Terabe, M., Matsui, S., Noben-Trauth, N., Chen, H., Watson, C., Donaldson, D.D., Carbone, D.P., Paul, W.E., Berzofsky, J.A. Nat. Immunol. (2000) [Pubmed]
  21. NKT cells promote antibody-induced joint inflammation by suppressing transforming growth factor beta1 production. Kim, H.Y., Kim, H.J., Min, H.S., Kim, S., Park, W.S., Park, S.H., Chung, D.H. J. Exp. Med. (2005) [Pubmed]
  22. Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation. Lappas, C.M., Day, Y.J., Marshall, M.A., Engelhard, V.H., Linden, J. J. Exp. Med. (2006) [Pubmed]
 
WikiGenes - Universities