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Gene Review

Pbx2  -  pre B cell leukemia homeobox 2

Mus musculus

Synonyms: AU043397, G17, Homeobox protein PBX2, Pre-B-cell leukemia transcription factor 2
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Disease relevance of Pbx2

  • Chlamydiae from mouse fibroblasts (McCoy cells) persistently infected with a trachoma strain (G17) of Chlamydia trachomatis repeatedly established new persistent infections in wild McCoy cells more rapidly than did wild chlamydiae [1].
  • An in vitro model of persistent infection of mouse fibroblasts (McCoy cells) with a trachoma strain (G17) of Chlamydia trachomatis has been developed [2].

High impact information on Pbx2

  • The potentiating effect of G17-Gly on G-17-induced acid secretion was associated with increased parietal cell activation but was independent of changes in parietal and enterochromaffin-like cell number, fundic proliferation rates, and H(+),K(+)-adenine triphosphatase expression [3].
  • Among PBC family members, Pbx2 and very low levels of Pbx3 were observed in the thymi of wild-type mice [4].
  • Therefore, the deficient postnatal T-lymphocytic potential of the Prep1 hematopoietic progenitors depends on the combined, not compensated, absence of Prep1 and at least Pbx2 [4].
  • Overall, we establish that, by controlling the spatial expression of Hox genes in the posterior limb and regulating ZPA function, Pbx1/Pbx2 exert a primary hierarchical function on Hox genes, rather than behaving merely as Hox ancillary factors [5].
  • Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression [5].

Biological context of Pbx2

  • 5. During early organogenesis, until E12.5, Pbx3 expression is found mostly in the embryonic head, forelimbs, and septum transversum, unlike Pbx1 and Pbx2 expression which is more widespread [6].
  • We examined apoptosis and the expression of Bcl-2 family proteins in INS-GAS mice of different ages, as well as in gastrin-deficient (GAS-KO) mice after gastrin-17 (G-17) infusion [7].
  • Pregnant ICR mice were subcutaneously injected with 0,5, or 3x3 mg Hg/kg of methylmercury (MeHg) on days 12,13, and 14(G12-14) of gestation and were sacrificed on G17 [8].
  • In the experiment with A/G17, A/SA-6, and C/TW-3 genetron vaccines, an extraordinary high antibody response was demonstrated [9].

Anatomical context of Pbx2

  • In this study, we first uncover that Pbx1 and Pbx2 are co-expressed in the lateral plate and early limb field mesoderm [5].
  • Characterization of the molecular forms of gastrin in these cell lines revealed that GH3 and Rin5-f processed gastrin in a manner similar to antral G-cells but the cleavage of the Lys74-Lys75 bond that converts G34 to G17 appeared to be suppressed in AtT-20 cells [10].

Other interactions of Pbx2

  • When fused with E2a, the Pbx-related proteins Pbx2 and Pbx3 were also transformation competent, demonstrating that all known members of this highly similar subfamily of homeodomain proteins have latent oncogenic potential [11].


  1. Factors affecting the rate as which a trachoma strain of Chlamydia trachomatis establishes persistent infections in mouse fibroblasts (McCoy cells). Lee, C.K. Infect. Immun. (1981) [Pubmed]
  2. Persistent infection of mouse fibroblasts (McCoy cells) with a trachoma strain of Chlamydia trachomatis. Lee, C.K., Moulder, J.W. Infect. Immun. (1981) [Pubmed]
  3. Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice. Chen, D., Zhao, C.M., Dockray, G.J., Varro, A., Van Hoek, A., Sinclair, N.F., Wang, T.C., Koh, T.J. Gastroenterology (2000) [Pubmed]
  4. Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors. Penkov, D., Di Rosa, P., Fernandez Diaz, L., Basso, V., Ferretti, E., Grassi, F., Mondino, A., Blasi, F. Mol. Cell. Biol. (2005) [Pubmed]
  5. Pbx1/Pbx2 requirement for distal limb patterning is mediated by the hierarchical control of Hox gene spatial distribution and Shh expression. Capellini, T.D., Di Giacomo, G., Salsi, V., Brendolan, A., Ferretti, E., Srivastava, D., Zappavigna, V., Selleri, L. Development (2006) [Pubmed]
  6. Spatio-temporal expression of Pbx3 during mouse organogenesis. Di Giacomo, G., Koss, M., Capellini, T.D., Brendolan, A., Pöpperl, H., Selleri, L. Gene Expr. Patterns (2006) [Pubmed]
  7. Gastrin-induced apoptosis contributes to carcinogenesis in the stomach. Cui, G., Takaishi, S., Ai, W., Betz, K.S., Florholmen, J., Koh, T.J., Houghton, J., Pritchard, D.M., Wang, T.C. Lab. Invest. (2006) [Pubmed]
  8. In utero methylmercury exposure differentially affects the activities of selenoenzymes in the fetal mouse brain. Watanabe, C., Yoshida, K., Kasanuma, Y., Kun, Y., Satoh, H. Environmental research. (1999) [Pubmed]
  9. Micro-immunofluorescence antibody responses to trachoma vaccines. Wang, S.P., Grayston, J.T. International ophthalmology. (1988) [Pubmed]
  10. Expression and post-translational processing of gastrin in heterologous endocrine cells. Marino, L.R., Takeuchi, T., Dickinson, C.J., Yamada, T. J. Biol. Chem. (1991) [Pubmed]
  11. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Monica, K., LeBrun, D.P., Dedera, D.A., Brown, R., Cleary, M.L. Mol. Cell. Biol. (1994) [Pubmed]
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