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Gene Review:

Pfn2 - profilin 2

Mus musculus

Synonyms: Pfn, Profilin II, Profilin-2

Gareus, R. et al., Di Nardo, A. et al., Poon, H.F. et al., Geese, M. et al., Witke, W. et al.

Witke, Sutherland, Sharpe, Arai, Kwiatkowski,

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Disease relevance of Pfn2

Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed [1].

High impact information on Pfn2

Although weakly expressed in early embryos, profilin II cannot compensate for lack of profilin I [2].
Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1 [3].
Overexpression of profilin 2 inhibits endocytosis, whereas lack of profilin 2 in neurons results in an increase in endocytosis and membrane recycling [3].
Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms [4].
We also found that the expression level of alpha-ATP synthase (Atp5a1) was significantly decreased, whereas the expression of profilin 2 (Pro-2) was significantly increased in brains from 12 mA SAMP8 mice [5].

Biological context of Pfn2

Here we describe the occurrence of two mouse profilin II isoforms, A and B, which are derived by alternative splicing [4].

References

Accumulation of profilin II at the surface of Listeria is concomitant with the onset of motility and correlates with bacterial speed. Geese, M., Schlüter, K., Rothkegel, M., Jockusch, B.M., Wehland, J., Sechi, A.S. J. Cell. Sci. (2000) [Pubmed]
Profilin I is essential for cell survival and cell division in early mouse development. Witke, W., Sutherland, J.D., Sharpe, A., Arai, M., Kwiatkowski, D.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
Mouse profilin 2 regulates endocytosis and competes with SH3 ligand binding to dynamin 1. Gareus, R., Di Nardo, A., Rybin, V., Witke, W. J. Biol. Chem. (2006) [Pubmed]
Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms. Di Nardo, A., Gareus, R., Kwiatkowski, D., Witke, W. J. Cell. Sci. (2000) [Pubmed]
Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein. Poon, H.F., Farr, S.A., Banks, W.A., Pierce, W.M., Klein, J.B., Morley, J.E., Butterfield, D.A. Brain Res. Mol. Brain Res. (2005) [Pubmed]

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PFN2	Bos taurus
pfn2l	Danio rerio
PFN2	Gallus gallus
PFN2	Homo sapiens
LOC713460	Macaca mulatta
PFN2	Pan troglodytes
LOC100909840	Rattus norvegicus
Pfn2	Rattus norvegicus
pfn2	Xenopus (Silurana) tropicalis

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