The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Pla2g4a  -  phospholipase A2, group IVA (cytosolic,...

Mus musculus

Synonyms: Cpla2, Cytosolic phospholipase A2, Phospholipase A2 group IVA, Pla2g4, Type IV PLA2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Pla2g4a


High impact information on Pla2g4a


Chemical compound and disease context of Pla2g4a


Biological context of Pla2g4a


Anatomical context of Pla2g4a


Associations of Pla2g4a with chemical compounds


Enzymatic interactions of Pla2g4a


Regulatory relationships of Pla2g4a

  • A peptide corresponding to the scaffolding domain of caveolin-1 (Cav-(82-101)) dramatically inhibited cPLA2 activity in purified hippocampal synaptoneurosomes [10].
  • The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse [23].
  • We propose that mechanical activation of the cPLA2 pathway contributes to acute high PIP-induced lung injury and that CCSP may reduce this injury through inhibition of the cPLA2 pathway and reduction of proinflammatory products produced by this pathway [11].
  • Addition of partially purified sPLA2 from BMMC enhanced cPLA2 activity and AA release [24].
  • These cells exhibit increased basal PG production, which is due to a constitutively stimulated cytosolic phospholipase A2 and enhanced basal expression of the remaining COX isozyme [25].

Other interactions of Pla2g4a

  • Our results raise the possibility that deprivation of COX-2 of its substrate by the suppression of cPLA2 mRNA expression is an additional mechanism used by NSAIDs to inhibit tumorigenesis [26].
  • The lack of sPLA2IB, sPLA2IIA, and sPLA2V mRNA expression in both NIH3T3 and MC3T3E1 cells suggests that cPLA2 is the most likely enzyme that catalyzes the release of AA, the rate-limiting substrate of COX for the production of PGs [26].
  • The results demonstrate a primary role for cPLA2 alpha in providing arachidonic acid for PGE2 production in mouse lung fibroblasts and support a role for this pathway in regulating collagen production [17].
  • These data suggest that sPLA2 mediate the selective release of AA by binding to cell surface receptors and then inducing signal transduction events that lead to cPLA2 activation [24].
  • In sum, there is no simple relationship between the ability of M phi s to release and metabolize AA, and the expression of cPLA2 or COX isoforms [27].

Analytical, diagnostic and therapeutic context of Pla2g4a


  1. Cytosolic phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in vitro. Vandal, O.H., Gelb, M.H., Ehrt, S., Nathan, C.F. Infect. Immun. (2006) [Pubmed]
  2. Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. Marusic, S., Leach, M.W., Pelker, J.W., Azoitei, M.L., Uozumi, N., Cui, J., Shen, M.W., DeClercq, C.M., Miyashiro, J.S., Carito, B.A., Thakker, P., Simmons, D.L., Leonard, J.P., Shimizu, T., Clark, J.D. J. Exp. Med. (2005) [Pubmed]
  3. Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Bonventre, J.V., Huang, Z., Taheri, M.R., O'Leary, E., Li, E., Moskowitz, M.A., Sapirstein, A. Nature (1997) [Pubmed]
  4. Acute lung injury by sepsis and acid aspiration: a key role for cytosolic phospholipase A2. Nagase, T., Uozumi, N., Ishii, S., Kume, K., Izumi, T., Ouchi, Y., Shimizu, T. Nat. Immunol. (2000) [Pubmed]
  5. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Clark, J.D., Lin, L.L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, N., Knopf, J.L. Cell (1991) [Pubmed]
  6. Deletion of cytosolic phospholipase A2 promotes striated muscle growth. Haq, S., Kilter, H., Michael, A., Tao, J., O'Leary, E., Sun, X.M., Walters, B., Bhattacharya, K., Chen, X., Cui, L., Andreucci, M., Rosenzweig, A., Guerrero, J.L., Patten, R., Liao, R., Molkentin, J., Picard, M., Bonventre, J.V., Force, T. Nat. Med. (2003) [Pubmed]
  7. Pharmacological comparison of UTP- and thapsigargin-induced arachidonic acid release in mouse RAW 264.7 macrophages. Lin, W.W., Chen, B.C. Br. J. Pharmacol. (1998) [Pubmed]
  8. Role of PKC and MAPK in cytosolic PLA2 phosphorylation and arachadonic acid release in primary murine astrocytes. Xu, J., Weng, Y.I., Simonyi, A., Krugh, B.W., Liao, Z., Weisman, G.A., Sun, G.Y., Simoni, A. J. Neurochem. (2002) [Pubmed]
  9. Basic fibroblast growth factor stimulates cytosolic phospholipase A2, phospholipase C-gamma1 and phospholipase D through distinguishable signaling mechanisms. Sa, G., Das, T. Mol. Cell. Biochem. (1999) [Pubmed]
  10. The caveolin scaffolding domain modifies 2-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor binding properties by inhibiting phospholipase A2 activity. Gaudreault, S.B., Chabot, C., Gratton, J.P., Poirier, J. J. Biol. Chem. (2004) [Pubmed]
  11. Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. Yoshikawa, S., Miyahara, T., Reynolds, S.D., Stripp, B.R., Anghelescu, M., Eyal, F.G., Parker, J.C. J. Appl. Physiol. (2005) [Pubmed]
  12. Phospholipase A2 is necessary for tumor necrosis factor alpha-induced ceramide generation in L929 cells. Jayadev, S., Hayter, H.L., Andrieu, N., Gamard, C.J., Liu, B., Balu, R., Hayakawa, M., Ito, F., Hannun, Y.A. J. Biol. Chem. (1997) [Pubmed]
  13. Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives. Hong, J., Sang, S., Park, H.J., Kwon, S.J., Suh, N., Huang, M.T., Ho, C.T., Yang, C.S. Carcinogenesis (2006) [Pubmed]
  14. A nuclear receptor ligand down-regulates cytosolic phospholipase A2 expression to reduce bile acid-induced cyclooxygenase 2 activity in cholangiocytes: implications of anticarcinogenic action of farnesoid X receptor agonists. Komichi, D., Tazuma, S., Nishioka, T., Hyogo, H., Chayama, K. Dig. Dis. Sci. (2005) [Pubmed]
  15. Cytosolic phospholipase A2alpha is crucial [correction of A2alpha deficiency is crucial] for 'on-time' embryo implantation that directs subsequent development. Song, H., Lim, H., Paria, B.C., Matsumoto, H., Swift, L.L., Morrow, J., Bonventre, J.V., Dey, S.K. Development (2002) [Pubmed]
  16. Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Fujishima, H., Sanchez Mejia, R.O., Bingham, C.O., Lam, B.K., Sapirstein, A., Bonventre, J.V., Austen, K.F., Arm, J.P. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  17. Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts. Ghosh, M., Stewart, A., Tucker, D.E., Bonventre, J.V., Murphy, R.C., Leslie, C.C. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  18. A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nagase, T., Uozumi, N., Ishii, S., Kita, Y., Yamamoto, H., Ohga, E., Ouchi, Y., Shimizu, T. Nat. Med. (2002) [Pubmed]
  19. Prostaglandin E2 amplifies cytosolic phospholipase A2- and cyclooxygenase-2-dependent delayed prostaglandin E2 generation in mouse osteoblastic cells. Enhancement by secretory phospholipase A2. Murakami, M., Kuwata, H., Amakasu, Y., Shimbara, S., Nakatani, Y., Atsumi, G., Kudo, I. J. Biol. Chem. (1997) [Pubmed]
  20. Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2. Meyer, A.M., Dwyer-Nield, L.D., Hurteau, G.J., Keith, R.L., O'Leary, E., You, M., Bonventre, J.V., Nemenoff, R.A., Malkinson, A.M. Carcinogenesis (2004) [Pubmed]
  21. A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. Bingham, C.O., Murakami, M., Fujishima, H., Hunt, J.E., Austen, K.F., Arm, J.P. J. Biol. Chem. (1996) [Pubmed]
  22. Regulation of cytosolic phospholipase A2 phosphorylation and eicosanoid production by colony-stimulating factor 1. Xu, X.X., Rock, C.O., Qiu, Z.H., Leslie, C.C., Jackowski, S. J. Biol. Chem. (1994) [Pubmed]
  23. The expression of brain cyclooxygenase-2 is down-regulated in the cytosolic phospholipase A2 knockout mouse. Bosetti, F., Weerasinghe, G.R. J. Neurochem. (2003) [Pubmed]
  24. Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells. Fonteh, A.N., Atsumi, G., LaPorte, T., Chilton, F.H. J. Immunol. (2000) [Pubmed]
  25. Nitric oxide synthase/COX cross-talk: nitric oxide activates COX-1 but inhibits COX-2-derived prostaglandin production. Clancy, R., Varenika, B., Huang, W., Ballou, L., Attur, M., Amin, A.R., Abramson, S.B. J. Immunol. (2000) [Pubmed]
  26. Transcriptional regulation of cyclooxygenase-2 gene expression: novel effects of nonsteroidal anti-inflammatory drugs. Yuan, C.J., Mandal, A.K., Zhang, Z., Mukherjee, A.B. Cancer Res. (2000) [Pubmed]
  27. Discordance between macrophage arachidonate metabolic phenotype and the expression of cytosolic phospholipase A2 and cyclooxygenase. Dolecki, G.J., Rogers, M., Lefkowith, J.B. Prostaglandins (1995) [Pubmed]
  28. Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation. Gilbert, J.J., Stewart, A., Courtney, C.A., Fleming, M.C., Reid, P., Jackson, C.G., Wise, A., Wakelam, M.J., Harnett, M.M. J. Immunol. (1996) [Pubmed]
  29. Association of cPLA2-alpha and COX-1 with the Golgi apparatus of A549 human lung epithelial cells. Grewal, S., Ponnambalam, S., Walker, J.H. J. Cell. Sci. (2003) [Pubmed]
  30. Integrative role of cPLA with COX-2 and the effect of non-steriodal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Kiaei, M., Kipiani, K., Petri, S., Choi, D.K., Chen, J., Calingasan, N.Y., Beal, M.F. J. Neurochem. (2005) [Pubmed]
  31. Interleukin-1 enhances the ATP-evoked release of arachidonic acid from mouse astrocytes. Stella, N., Estellés, A., Siciliano, J., Tencé, M., Desagher, S., Piomelli, D., Glowinski, J., Prémont, J. J. Neurosci. (1997) [Pubmed]
  32. What knockout mice can tell us about parturition. Kimura, T., Ogita, K., Kusui, C., Ohashi, K., Azuma, C., Murata, Y. Rev. Reprod. (1999) [Pubmed]
WikiGenes - Universities