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Gene Review:

Prl8a6 - prolactin family 8, subfamily a, member 6

Mus musculus

Synonyms: PLP C-alpha, PLP-C1, PLP-Ca, PLP-calpha, PRL-like protein C1, ...

Konola, J.T. et al., Dai, G. et al., Dai, G. et al.

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Disease relevance of Prl8a6

Screening of a rat genomic library with a PLP-C cDNA resulted in the isolation of four phage clones [1].

High impact information on Prl8a6

Expression of mouse PLP-C alpha increases dramatically as gestation advances and is restricted to spongiotrophoblast and trophoblast giant cells of the junctional zone [2].
Mouse PLP-C alpha maps to chromosome 13 along with other members of the mouse PRL family [2].
In conclusion, we have identified a new member of the PRL family possessing considerable homology to PLP-C, a unique gene structure, and displaying a trophoblast-specific pattern of transcriptional activation [1].
Nucleotide sequence analysis of the clones revealed a gene, PLP-Cv, closely related but distinct from PLP-C [1].
The permeabilized oligodendrocytes stained intensely for the PLP C-terminus, myelin basic protein, and beta-tubulin [3].

Anatomical context of Prl8a6

Fixation alone was sufficient for partial permeabilization of oligodendrocytes to antibodies and resulted in limited staining of the PLP C-terminus and intracellular proteins [3].
Expression of PLP-Cv was restricted to the trophoblast lineage and was coordinately activated with PLP-C beginning at day 11 of gestation and continuing until term [1].

Other interactions of Prl8a6

Finally, trypsinization of living oligodendrocytes eliminated surface myelin-oligodendrocyte glycoprotein staining but did not change the immunostaining properties of the PLP C-terminus [3].
Cells were examined by double-label indirect immunofluorescence for the presence of the PLP C-terminus and either oligodendrocyte-specific surface or intracellular antigens [3].

References

Prolactin-like protein-C variant: complementary deoxyribonucleic acid, unique six exon gene structure, and trophoblast cell-specific expression. Dai, G., Liu, B., Szpirer, C., Levan, G., Kwok, S.C., Soares, M.J. Endocrinology (1996) [Pubmed]
A new member of the mouse prolactin (PRL)-like protein-C subfamily, PRL-like protein-C alpha: structure and expression. Dai, G., Chapman, B.M., Liu, B., Orwig, K.E., Wang, D., White, R.A., Preuett, B., Soares, M.J. Endocrinology (1998) [Pubmed]
Orientation of the myelin proteolipid protein C-terminus in oligodendroglial membranes. Konola, J.T., Yamamura, T., Tyler, B., Lees, M.B. Glia (1992) [Pubmed]

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