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Gene Review

Psmc3ip  -  proteasome (prosome, macropain) 26S...

Mus musculus

Synonyms: C79099, GT198, HOP2, Homologous-pairing protein 2 homolog, Hop2, ...
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Disease relevance of Psmc3ip

  • Disruption of meiosis-specific HOP2 or MND1 genes leads to severe defects in homologous synapsis and an early-stage recombination failure resulting in sterility [1].

High impact information on Psmc3ip

  • We also show that coiled-coil motifs in Hop2 and Mnd1 are essential for their interaction with each other and that a clearly delineated region near the COOH terminus of both proteins is necessary for both the DNA binding and single-strand annealing by the Hop-Mnd1 heterodimer [2].
  • Finally, we describe a point mutation in Hop2 that dissociates its strand invasion activity from its ability to bind and anneal DNA [2].
  • The TBPIP/HOP2 protein is a factor that ensures the proper pairing of homologous chromosomes during meiosis [3].
  • Our radiation hybrid mapping indicates that TBPIP is located on chromosome 17q12-21 [4].
  • Eighty-eight per cent of the deduced amino acid sequence of human TBPIP coincides with that of mouse TBPIP [4].

Biological context of Psmc3ip


Anatomical context of Psmc3ip


Other interactions of Psmc3ip

  • Here we show that mouse Hop2 can efficiently form D-loops, the first recombination intermediates, but this activity is abrogated upon association with Mnd1 [1].

Analytical, diagnostic and therapeutic context of Psmc3ip

  • Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP [6].
  • Immunofluorescence analysis of meiotic chromosome spreads indicates that while meiotic double-stranded breaks are formed and processed in the Hop2 knockout, they fail to be repaired [5].


  1. The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. Petukhova, G.V., Pezza, R.J., Vanevski, F., Ploquin, M., Masson, J.Y., Camerini-Otero, R.D. Nat. Struct. Mol. Biol. (2005) [Pubmed]
  2. Molecular activities of meiosis-specific proteins Hop2, Mnd1, and the Hop2-Mnd1 complex. Pezza, R.J., Petukhova, G.V., Ghirlando, R., Camerini-Otero, R.D. J. Biol. Chem. (2006) [Pubmed]
  3. Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. Enomoto, R., Kinebuchi, T., Sato, M., Yagi, H., Shibata, T., Kurumizaka, H., Yokoyama, S. J. Biol. Chem. (2004) [Pubmed]
  4. Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene. Ijichi, H., Tanaka, T., Nakamura, T., Yagi, H., Hakuba, A., Sato, M. Gene (2000) [Pubmed]
  5. The Hop2 protein has a direct role in promoting interhomolog interactions during mouse meiosis. Petukhova, G.V., Romanienko, P.J., Camerini-Otero, R.D. Dev. Cell (2003) [Pubmed]
  6. Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP. Tanaka, T., Nakamura, T., Takagi, H., Sato, M. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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