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Gene Review: 

Psme2  -  proteasome (prosome, macropain) activator...

Mus musculus

Synonyms: 11S regulator complex subunit beta, AA589371, AI788882, Activator of multicatalytic protease subunit 2, PA28b, ...
 
 
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High impact information on Psme2

  • It is shown here that mice with a disrupted PA28b gene lack PA28a and PA28b polypeptides, demonstrating that PA28 functions as a hetero-oligomer in vivo [1].
  • By fluorescence in situ hybridization, the location of the two PA28b genes was determined on chromosomes 11 and 14 [2].
  • Interspecific backcross mapping showed that the mouse genes coding for the alpha- and beta-subunits (designated Psme1 and Psme2, respectively) are tightly linked and map close to the Atp5g1 locus on chromosome 14 [3].
  • Southern blot analysis suggests that both PA28a and PA28b are multiple-copy genes, while Ki is a single-copy gene [4].
 

Biological context of Psme2

References

  1. Impaired immunoproteasome assembly and immune responses in PA28-/- mice. Preckel, T., Fung-Leung, W.P., Cai, Z., Vitiello, A., Salter-Cid, L., Winqvist, O., Wolfe, T.G., Von Herrath, M., Angulo, A., Ghazal, P., Lee, J.D., Fourie, A.M., Wu, Y., Pang, J., Ngo, K., Peterson, P.A., Früh, K., Yang, Y. Science (1999) [Pubmed]
  2. Characterization of the mouse proteasome regulator PA28b gene. Li, Y., Chambers, J., Pang, J., Ngo, K., Peterson, P.A., Leung, W.P., Yang, Y. Immunogenetics (1999) [Pubmed]
  3. PA28 subunits of the mouse proteasome: primary structures and chromosomal localization of the genes. Kandil, E., Kohda, K., Ishibashi, T., Tanaka, K., Kasahara, M. Immunogenetics (1997) [Pubmed]
  4. Sequence and expression of mouse proteasome activator PA28 and the related autoantigen Ki. Jiang, H., Monaco, J.J. Immunogenetics (1997) [Pubmed]
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