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Gene Review

Ptma  -  prothymosin alpha

Mus musculus

Synonyms: Prothymosin alpha, Thym
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Disease relevance of Ptma


High impact information on Ptma


Biological context of Ptma


Anatomical context of Ptma


Associations of Ptma with chemical compounds

  • Interestingly, cycling cells that were synchronized at different stages of the cycle by means of mitotic shake off after nocodazole arrest or double thymidine block did not show variations in the levels of PT-alpha mRNA when progressed synchronously through the cycle [13].
  • PT-alpha mRNA induction seems to require the synthesis of proteic factor(s) since PT-alpha mRNA response to serum restoration was abolished in the presence of cycloheximide [13].
  • The complete murine prothymosin alpha molecule (110 residues) except for the N-terminal methionine deduced from the cloned cDNA has been synthesized by a solid-phase method [14].

Regulatory relationships of Ptma


Other interactions of Ptma


Analytical, diagnostic and therapeutic context of Ptma


  1. Transgenic overexpression of prothymosin alpha induces development of polycystic kidney disease. Li, K.J., Shiau, A.L., Chiou, Y.Y., Yo, Y.T., Wu, C.L. Kidney Int. (2005) [Pubmed]
  2. The pattern of prothymosin alpha gene expression coincides with that of myc proto-oncogenes during mouse embryogenesis. Moll, J., Schmid, P., Sansig, G., van der Putten, H. Histochem. J. (1996) [Pubmed]
  3. Spasmolytic polypeptide expressing metaplasia to preneoplasia in H. felis-infected mice. Nomura, S., Baxter, T., Yamaguchi, H., Leys, C., Vartapetian, A.B., Fox, J.G., Lee, J.R., Wang, T.C., Goldenring, J.R. Gastroenterology (2004) [Pubmed]
  4. Enhancement of humoral and cellular immune responses by an oral Salmonella choleraesuis vaccine expressing porcine prothymosin alpha. Shiau, A.L., Chen, C.C., Yo, Y.T., Chu, C.Y., Wang, S.Y., Wu, C.L. Vaccine (2005) [Pubmed]
  5. Does prothymosin alpha affect the phosphorylation of elongation factor 2? Enkemann, S.A., Pavur, K.S., Ryazanov, A.G., Berger, S.L. J. Biol. Chem. (1999) [Pubmed]
  6. Prothymosin alpha stimulates Ca2+-dependent phosphorylation of elongation factor 2 in cellular extracts. Vega, F.V., Vidal, A., Hellman, U., Wernstedt, C., Domínguez, F. J. Biol. Chem. (1998) [Pubmed]
  7. A 180-kDa protein kinase seems to be responsible for the phosphorylation of prothymosin alpha observed in proliferating cells. Pérez-Estévez, A., Díaz-Jullien, C., Covelo, G., Salgueiro, M.T., Freire, M. J. Biol. Chem. (1997) [Pubmed]
  8. Prothymosin alpha is phosphorylated in proliferating stimulated cells. Barcia, M.G., Castro, J.M., Jullien, C.D., Freire, M. J. Biol. Chem. (1993) [Pubmed]
  9. The prothymosin alpha gene is specifically expressed in ectodermal and mesodermal regions during early postimplantation mouse embryogenesis. Franco del Amo, F., Freire, M. FEBS Lett. (1995) [Pubmed]
  10. Prothymosin alpha expression occurs during G1 in proliferating B or T lymphocytes. Szabo, P., Ehleiter, D., Whittington, E., Weksler, M.E. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  11. Depression of prothymosin alpha production in murine thymus correlates with staphylococcal enterotoxin-B-induced immunosuppression [corrected]. Low, T.L., Pan, T.L., Lin, Y.S. FEBS Lett. (1990) [Pubmed]
  12. Metabolic regulation of protein-bound glutamyl phosphates: insights into the function of prothymosin alpha. Tao, L., Wang, R.H., Enkemann, S.A., Trumbore, M.W., Berger, S.L. J. Cell. Physiol. (1999) [Pubmed]
  13. Prothymosin alpha mRNA levels are invariant throughout the cell cycle. Zalvide, J.B., Cancio, E., Alvarez, C.V., Regueiro, B.J., Dominguez, F. J. Biol. Chem. (1992) [Pubmed]
  14. Synthesis of prothymosin alpha deduced from nucleotide sequence of the murine cDNA and its effect on the impaired T lymphocytes of uremic patients. Abiko, T., Sekino, H. Biotechnology therapeutics. (1993) [Pubmed]
  15. Complex regulation of prothymosin alpha in mammary tumors arising arising in transgenic mice. Loidi, L., García-Caballero, T., Vidal, A., Zalvide, J., Gallego, R., Domínguez, F. Life Sci. (1999) [Pubmed]
  16. Prothymosin alpha is an evolutionary conserved protein covalently linked to a small RNA. Makarova, T., Grebenshikov, N., Egorov, C., Vartapetian, A., Bogdanov, A. FEBS Lett. (1989) [Pubmed]
  17. Prothymosin alpha enhances protective immune responses induced by oral DNA vaccination against pseudorabies delivered by Salmonella choleraesuis. Shiau, A.L., Chen, Y.L., Liao, C.Y., Huang, Y.S., Wu, C.L. Vaccine (2001) [Pubmed]
  18. Thymosinalpha1 is chemopreventive for lung adenoma formation in A/J mice. Moody, T.W., Leyton, J., Zia, F., Tuthill, C., Badamchian, M., Goldstein, A.L. Cancer Lett. (2000) [Pubmed]
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