Disease relevance of Rab20

• In a large-scale analysis of gene expression in pancreatic cancer, we isolated the homologue of the mouse Rab20 [1].
• Rab20 expression was detected by Western blot analysis in 11 of 11 pancreatic tumor cell lines and 7 of 8 primary pancreatic carcinomas [1].
• Immunohistochemical analysis of Rab20 in tissues showed low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas [1].

High impact information on Rab20

• Rab20 was also detected in preneoplastic pancreatic intraductal neoplasia lesions, suggesting that its up-regulation may be an early event in pancreatic carcinogenesis [1].
• Genetic mapping of Rab20 on mouse chromosome 8 [2].
• CONCLUSIONS: The immunohistochemical data in combination with the membrane fractionation studies are consistent with a potential role for Rab11 and Rab20 in regulating V-ATPase traffic in specific segments of the nephron [3].

Other interactions of Rab20

• Rab11 and Rab20 were enriched in membrane fractions that were also enriched in V-ATPase B2 and B1 subunit isoforms, respectively [3].

Analytical, diagnostic and therapeutic context of Rab20

• Using immunofluorescence and immunoelectron microscopy, we localized the Rab20 protein in the vicinity of the Golgi apparatus [1].

References