Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Rad1 - RAD1 homolog (S. pombe)

Mus musculus

Synonyms: Cell cycle checkpoint protein RAD1, DNA repair exonuclease rad1 homolog, Rad1-like DNA damage checkpoint protein, Rec1, mRAD1

Bluyssen, H.A. et al., Barnes, E.A. et al.

Bluyssen, van Os, Naus, Jaspers, Hoeijmakers, de Klein,

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High impact information on Rad1

Speedy (Spy1) is a novel cell cycle regulator that binds and activates cdk2, and was originally identified as a suppressor of Rad1 deficiency in Schizosaccharomyces pombe [1].
The human RAD1 and mRAD1 messengers are highly expressed in the testis as different mRNA species (varying from 1.0, 1.4, 1.5, to 3.0 kb) [2].
The human RAD1 open reading frame (ORF) encodes a protein of 282 amino acids; the mRAD1 ORF codes for a protein of 280 amino acids [2].

References

Human Spy1 promotes survival of mammalian cells following DNA damage. Barnes, E.A., Porter, L.A., Lenormand, J.L., Dellinger, R.W., Donoghue, D.J. Cancer Res. (2003) [Pubmed]
A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. Bluyssen, H.A., van Os, R.I., Naus, N.C., Jaspers, I., Hoeijmakers, J.H., de Klein, A. Genomics (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP002255	Anopheles gambiae str. PEST
RAD1	Bos taurus
mrt-2	Caenorhabditis elegans
RAD1	Canis lupus familiaris
rad1	Danio rerio
Rad1	Drosophila melanogaster
RAD1	Gallus gallus
RAD1	Homo sapiens
RAD1	Macaca mulatta
MGG_17052	Magnaporthe oryzae 70-15
NCU00942	Neurospora crassa OR74A
RAD1	Pan troglodytes
Rad1	Rattus norvegicus
rad1	Schizosaccharomyces pombe 972h-
rad1	Xenopus (Silurana) tropicalis

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