High impact information on Rasgrf2

• Targeted disruption of Ras-Grf2 shows its dispensability for mouse growth and development [1].
• The mammalian Grf1 and Grf2 proteins are Ras guanine nucleotide exchange factors (GEFs) sharing a high degree of structural homology, as well as an elevated expression level in central nervous system tissues [1].
• Ras-GRF2 also contains an IQ motif which was required for its apparent constitutive association with calmodulin in epithelial cells ectopically expressing Ras-GRF2 [2].
• Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene [3].
• Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression [4].

Anatomical context of Rasgrf2

• In this study, using mouse brain extracts, we show that both RasGRF1 and RasGRF2 interact with microtubules in an in vitro microtubule assembly system and this binding is very tight [5].

Other interactions of Rasgrf2

• These findings show that, despite their similar functional domain organization, Ras-GRF1 and Ras-GRF2 mediate opposing forms of synaptic plasticity by coupling different classes of NMDARs to distinct MAP kinase pathways [4].

Analytical, diagnostic and therapeutic context of Rasgrf2

• To gain insight into the in vivo function of Grf2, we disrupted its catalytic CDC25-H domain by means of gene targeting [1].

References