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Gene Review:

Rb(7.18)9Lub - Robertsonian translocation, Chr 7 and 18,...

Mus musculus

Synonyms: Rb9Lub

Eppig, J.T. et al., Haigis, K.M. et al., Lane, P.W. et al.

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Disease relevance of Rb(7.18)9Lub

We report that the Robertsonian translocation Rb(7.18)9Lub (Rb9) suppresses the multiplicity of intestinal adenomas in this mouse model [1].

High impact information on Rb(7.18)9Lub

In a backcross using the Robertsonian translocation Rb(7.18)9Lub (Rb9) as the centromeric marker, the centromere-Gpi-1 recombination percentage was 4.5 +/- 1.3, demonstrating that Rb9 suppresses recombination near the centromere of chromosome 7 [2].
The Robertsonian translocation Rb(7.18)9Lub was found to suppress crossing over in the proximal half of this chromosome [3].

References

A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Haigis, K.M., Dove, W.F. Nat. Genet. (2003) [Pubmed]
Analysis of recombination in the centromere region of mouse chromosome 7 using ovarian teratoma and backcross methods. Eppig, J.T., Eicher, E.M. J. Hered. (1988) [Pubmed]
Location of plucked (pk) on chromosome 18 of the mouse. Lane, P.W., Eicher, E.M. J. Hered. (1985) [Pubmed]

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