Gene Review:
Rln1 - relaxin 1
Mus musculus
Synonyms:
Prorelaxin 1, Rln, Rlx, rlx
Kostic,
Parry,
Bond,
Unemori,
Baumann,
Schwabe,
Siebel,
Gehring,
Reytomas,
Samuel,
Mak,
Parry,
Siebel,
Tregear,
Gehring,
Dawson,
Summers,
Wade,
McGuane,
Siebel,
Du,
Reytomas,
Burazin,
Zhao,
Vodstrcil,
Bathgate,
Büllesbach,
Layfield,
Gehring,
Samuel,
Bathgate,
Tregear,
Bartsch,
Layfield,
Mookerjee,
Dschietzig,
Claasz,
Parry,
Parry,
Stangl,
Kinkel,
- Relaxin: new peptides, receptors and novel actions. Bathgate, R.A., Samuel, C.S., Burazin, T.C., Gundlach, A.L., Tregear, G.W. Trends Endocrinol. Metab. (2003)
- Genetic targeting of relaxin and insulin-like factor 3 receptors in mice. Kamat, A.A., Feng, S., Bogatcheva, N.V., Truong, A., Bishop, C.E., Agoulnik, A.I. Endocrinology (2004)
- Functional expression of mouse relaxin and mouse relaxin-3 in the lung from an Ebola virus glycoprotein-pseudotyped lentivirus via tracheal delivery. Silvertown, J.D., Walia, J.S., Summerlee, A.J., Medin, J.A. Endocrinology (2006)
- Mechanisms of relaxin action in the reproductive tract: studies in the relaxin-deficient (Rlx-/-) mouse. Parry, L.J., McGuane, J.T., Gehring, H.M., Kostic, I.G., Siebel, A.L. Ann. N. Y. Acad. Sci. (2005)
- The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs. Lekgabe, E.D., Royce, S.G., Hewitson, T.D., Tang, M.L., Zhao, C., Moore, X.L., Tregear, G.W., Bathgate, R.A., Du, X.J., Samuel, C.S. Endocrinology (2006)
- Relaxin plays an important role in the regulation of airway structure and function. Samuel, C.S., Royce, S.G., Burton, M.D., Zhao, C., Tregear, G.W., Tang, M.L. Endocrinology (2007)
- Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis. Xu, Q., Lekgabe, E.D., Gao, X.M., Ming, Z., Tregear, G.W., Dart, A.M., Bathgate, R.A., Samuel, C.S., Du, X.J. Endocrinology (2008)
- Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Chehab, F.F., Lim, M.E., Lu, R. Nat. Genet. (1996)
- Relaxin's physiological roles and other diverse actions. Sherwood, O.D. Endocr. Rev. (2004)
- Relaxin-1-deficient mice develop an age-related progression of renal fibrosis. Samuel, C.S., Zhao, C., Bond, C.P., Hewitson, T.D., Amento, E.P., Summers, R.J. Kidney Int. (2004)
- Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. Unemori, E.N., Pickford, L.B., Salles, A.L., Piercy, C.E., Grove, B.H., Erikson, M.E., Amento, E.P. J. Clin. Invest. (1996)
- Relaxin up-regulates the nitric oxide biosynthetic pathway in the mouse uterus: involvement in the inhibition of myometrial contractility. Bani, D., Baccari, M.C., Nistri, S., Calamai, F., Bigazzi, M., Sacchi, T.B. Endocrinology (1999)
- Myocardial relaxin counteracts hypertrophy in hypertensive rats. Dschietzig, T., Bartsch, C., Kinkel, T., Baumann, G., Stangl, K. Ann. N. Y. Acad. Sci. (2005)
- Inhibition of oxytocin receptor and estrogen receptor-alpha expression, but not relaxin receptors (LGR7), in the myometrium of late pregnant relaxin gene knockout mice. Siebel, A.L., Gehring, H.M., Reytomas, I.G., Parry, L.J. Endocrinology (2003)
- Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) mice. Siebel, A.L., Gehring, H.M., Vodstrcil, L., Parry, L.J. Ann. N. Y. Acad. Sci. (2005)
- A novel Leydig cell cDNA-derived protein is a relaxin-like factor. Büllesbach, E.E., Schwabe, C. J. Biol. Chem. (1995)
- Endocrine effects of relaxin overexpression in mice. Feng, S., Bogatcheva, N.V., Kamat, A.A., Truong, A., Agoulnik, A.I. Endocrinology (2006)
- Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo. Samuel, C.S., Unemori, E.N., Mookerjee, I., Bathgate, R.A., Layfield, S.L., Mak, J., Tregear, G.W., Du, X.J. Endocrinology (2004)
- Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family. Bathgate, R.A., Samuel, C.S., Burazin, T.C., Layfield, S., Claasz, A.A., Reytomas, I.G., Dawson, N.F., Zhao, C., Bond, C., Summers, R.J., Parry, L.J., Wade, J.D., Tregear, G.W. J. Biol. Chem. (2002)
- Mice without a functional relaxin gene are unable to deliver milk to their pups. Zhao, L., Roche, P.J., Gunnersen, J.M., Hammond, V.E., Tregear, G.W., Wintour, E.M., Beck, F. Endocrinology (1999)
- Collagen studies in late pregnant relaxin null mice. Zhao, L., Samuel, C.S., Tregear, G.W., Beck, F., Wintour, E.M. Biol. Reprod. (2000)
- Evidence for local relaxin ligand-receptor expression and function in arteries. Novak, J., Parry, L.J., Matthews, J.E., Kerchner, L.J., Indovina, K., Hanley-Yanez, K., Doty, K.D., Debrah, D.O., Shroff, S.G., Conrad, K.P. FASEB J. (2006)
- Relaxin favors the morphofunctional integration between skeletal myoblasts and adult cardiomyocytes in coculture. Formigli, L., Francini, F., Chiappini, L., Zecchi-Orlandini, S., Bani, D. Ann. N. Y. Acad. Sci. (2005)
- The primary structure and the disulfide links of the bovine relaxin-like factor (RLF). Büllesbach, E.E., Schwabe, C. Biochemistry (2002)