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SPRED2  -  sprouty-related, EVH1 domain containing 2

Homo sapiens

Synonyms: FLJ21897, FLJ31917, Spred-2, Sprouty-related, EVH1 domain-containing protein 2
 
 
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Disease relevance of SPRED2

  • Studies on endogenous Spred-2 in ME4405 melanoma cells showed that pervanadate induced Spred-2 ubiquitination and a marked reduction in Spred-2 steady-state levels that was partially blocked by the proteasomal inhibitor, MG-132 [1].
 

High impact information on SPRED2

 

Biological context of SPRED2

 

Analytical, diagnostic and therapeutic context of SPRED2

References

  1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. Lock, P., I, S.T., Straffon, A.F., Schieb, H., Hovens, C.M., Stylli, S.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
 
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