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Gene Review

SPRED2  -  sprouty-related, EVH1 domain containing 2

Homo sapiens

Synonyms: FLJ21897, FLJ31917, Spred-2, Sprouty-related, EVH1 domain-containing protein 2
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Disease relevance of SPRED2

  • Studies on endogenous Spred-2 in ME4405 melanoma cells showed that pervanadate induced Spred-2 ubiquitination and a marked reduction in Spred-2 steady-state levels that was partially blocked by the proteasomal inhibitor, MG-132 [1].

High impact information on SPRED2


Biological context of SPRED2


Analytical, diagnostic and therapeutic context of SPRED2


  1. Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination. Lock, P., I, S.T., Straffon, A.F., Schieb, H., Hovens, C.M., Stylli, S.S. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
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